Biologic Specimen and Data Repository Information Coordinating Center

ACCESS examined the etiology of sarcoidosis, as well as socioeconomic variables and the clinical course of patients with sarcoidosis, including quality of life.

ACCORD investigated if intensive glycemic control, multiple lipid management, and intensive blood pressure control could prevent major cardiovascular events in adults with type 2 diabetes mellitus. The EYE and MIND sub-studies additionally evaluated the interventions' effects on the progression of diabetic retinopathy and the brain (cognition and structure), respectively. The ACCORDION follow-up study examined the long-term effects of the ACCORD treatment strategies.

PACTG was a controlled Phase III trial designed to determine if HIVIG given to HIV-positive pregnant women during the second and third trimester of pregnancy reduced the likelihood of maternal-fetal HIV transmission.

COAG tested whether genotype-guided dosing of warfarin improves anticoagulation control during the first 4 weeks of therapy when compared to clinical-guided dosing.

CSSCD examined the natural history of sickle cell disease from birth to death in order to identify factors contributing to the morbidity and mortality of the disease. Biospecimens from adult subjects who attended the 2A follow-up study are available for request. Phase 2A of the study examined the progression of organ damage in the heart, lung, kidney and liver in adult cohort patients enrolled in phase 1 of the study.

The goal of the study is to generate a Sickle Cell Disease peripheral blood stem cell repository. Volunteer sickle cell disease patients were mobilized with plerixafor and peripheral blood stem cells were collected by apheresis.

DASH tested the effects of dietary patterns characterized by high intakes of certain minerals and fiber associated with low blood pressure compared with each other and with a control dietary pattern mirroring US consumption.

As a follow-up to DASH, DASH-Sodium tested the effects of two dietary patterns and three sodium intake levels on blood pressure in pre-hypertensive and stage 1 hypertensive adults.

DISC evaluated the efficacy and safety of a lipid lowering diet in 8 to 10 year old children with elevated LDL cholesterol after at least 3 years of follow-up.

The DISC06 follow-up study examined the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults.

HEIRS evaluated the prevalence, genetic, and environmental determinants and potential clinical, personal, and societal impact of iron overload and hereditary hemochromatosis in adults.

HHP investigated environmental and biological causes of morbidity and mortality from CHD and stoke among Japanese Americans living in Honolulu in comparison to other populations.

BABY HUG consists of a randomized controlled trial and two observational follow-up studies. The trial found that hydroxyurea can be considered safe and effective for all very young children with sickle cell anemia.

The LTRC was a biobank resource that collected lung tissue, blood samples, clinical data, and radiographic studies from participants with chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, other related idiopathic interstitial pneumonias and interstitial pneumonias associated with connective tissue diseases who undergo medically-indicated lung resection.

MHCS-I evaluated and prospectively followed patients with hemophilia or a related coagulation disorder in order to understand the cause and natural history of HIV infection and AIDS in this population which was at high risk for development of AIDS. MHCS-II evaluated and prospectively followed a cohort of subjects with hemophilia who were exposed to hepatitis C virus in order to quantify the rates of liver decompensation, hepatocellular carcinoma, and non-Hodgkin lymphoma, evaluate causal markers, identify predictive markers, identify genes that confer susceptibility or resistance, and identify response and complication rates of anti-HCV and anti-HIV treatment regimens.

MSH evaluated whether or not treatment with hydroxyurea titrated to maximum tolerated doses would reduce the frequency of vaso-occlusive (painful) crises by at least 50%. This controlled trial made hydroxyurea the first drug of proven benefit in the prevention of vaso-occlusive pain crisis and acute chest syndrome caused by sickle cell disease.

NGHS assessed racial differences in dietary, physical activity, family, and psychosocial factors associated with the development of obesity from pre-adolescence through maturation between African-American and Caucasian girls. Secondarily, NGHS examined the effects of obesity on CVD risk factors.

CBB specimens were collected under the Cord Blood Transplantation Study Cord Blood Banking program with the objective of building an ethnically diverse unrelated cord blood bank and developing standard operating procedures for umbilical cord blood donor recruitment, selection and banking.

The overall objective of GenTAC was to establish a registry of patients with genetically induced thoracic aortic aneurysms and related cardiovascular conditions, and collect associated medical data, as well as blood and tissue samples and make them available to investigators to advance research in diagnosis and management of genetically induced thoracic aortic aneurysms.

NANB-TAH was an extended follow-up study of 5 major prospective studies of transfusion-associated hepatitis that attempted to address the uncertainty about the frequency progression to clinically symptomatic and debilitating chronic liver disease and the frequency of fatal liver disease. The study, designed to track both mortality and morbidity of transfusion-associated non-A, non-B hepatitis, was a natural history evaluation that began at the time of disease onset and monitored subjects for almost 25 years.

OMNI Heart compared the effects of three healthy diets, each with reduced saturated fat intake, on blood pressure and serum lipids in adults with pre-hypertension or stage 1 hypertension.

PREMIER compared the effects on blood pressure of two multi-component behavioral interventions and an advice only group over a period of 18 months. The two behavioral interventions promoted established recommendations that reduce blood pressure and one intervention additionally promoted the DASH diet.

P2C2 aimed to determine the prevalence and natural history of pulmonary and cardiac complications associated with HIV infection in utero, in infancy, and during early childhood.

PEACE tested the hypothesis that patients with stable coronary artery disease and normal or slightly reduced left ventricular function derive therapeutic benefit from the addition of ACE inhibitors to conventional therapy.

SPIROMICS sought to identify homogeneous subgroups of chronic obstructive pulmonary disease patients for targeted enrollment in future therapeutic clinical trials, as well as to identify and conduct preliminary validation of intermediate biological or clinical outcomes for use as clinical trial endpoints.

SPRINT tested the hypothesis that treating systolic blood pressure to a goal lower than the current recommendation would reduce the incidence of CVD.

LHMP brought the distinct efforts of six clinical centers together under a single infrastructure, creating a collaborative network. The goals of the project were to characterize the microbiome of the lung and respiratory tract, and enhance understanding of the role of the lung microbiome in preserving health or causing disease and in the divergent effects observed in HIV-infected versus uninfected individuals.

TIMI II assessed whether intravenous tissue-type plasminogen activator given in the early hours of acute myocardial infarction should be followed by percutaneous transluminal coronary angioplasty.

TSS established two donor-recipient repositories consisting of a serum repository from donors in high AIDS prevalence areas in the U.S. and a plasma and cell repository from blood donors, transfusion and other blood product recipients and control cohorts. The repository has been used to evaluate factors influencing the risk of transfusion-transmitted HIV infection and its progression to clinically significant manifestations.

TTVS established a repository of specimens collected from prospectively identified cases of non-A, non-B (NANB) hepatitis after blood transfusion. The major intentions were to determine the incidence of that occurrence, identify the characteristics of the donors associated with the event and have a resource available to compare laboratory donor screening methods during the study and in subsequent years following completion of the study.

TOPCAT evaluated the effectiveness of aldosterone antagonist therapy in reducing cardiovascular mortality, aborted cardiac arrest, and heart failure hospitalization in patients who have heart failure with preserved systolic function.

VA2-TAH was designed to test the efficacy of hepatitis B immune serum globulin for the prevention or modification of post-transfusion hepatitis as compared to immune serum globulin.

WLM compared the long-term effects of two weight loss maintenance intervention groups, one receiving behavioral intervention through personal counseling and the other receiving behavioral intervention through web-based individually tailored interactive technology, versus a self-directed/usual care control group.

WNV was a longitudinal natural history study that enrolled West Nile Virus viremic donors in order to characterize viral and immunological parameters.