Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)

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Accession Number
HLB01890909a

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1994-1995

NHLBI Division
DBDR

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00005278

Primary Publication URLs
N/A

Consent

Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.

Objectives

To provide researchers with an opportunity to conduct studies on a large representative sample of blood donors with linked demographic data and donation test results. Targeted investigations on particular subsets of the donor population are also feasible due to the availability of this linked data.

Background

The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. One of the aims of this study is to establish blood specimen repositories for future testing. The General Leukocyte and Plasma Repository (GLPR) was established under this study.

The GLPR repository has already been used to investigate HHV-8 antibody prevalence in the US blood supply (1) and polymorphisms in chemokine receptor genes (2).

Subjects

The GLPR was collected in 1994 and 1995 and consists of aliquots of plasma, and whole blood frozen, with or without DMSO, obtained from 147,915 blood donations.

Design

Specimens for the GLPR repository were collected according to a statistical sampling plan, designed to obtain donations that are representative of all donor racial/ethnic groups. REDS blood centers that have contributed to the GLPR repository include: the American Red Cross (ARC) Greater Chesapeake and Potomac (Baltimore, MD; and Washington, DC), Southeastern Michigan (Detroit, MI), and Southern California (Los Angeles, CA) regions; the Blood Centers of the Pacific (BCP; San Francisco, CA); and the Oklahoma Blood Institute (Oklahoma City, OK).

Donor screening and testing was performed according to standard operating procedures and included tests for anti-HIV (types 1 and 2), anti-HCV, anti-HTLV, HBsAg and anti-HBc; serologic testing for syphilis and testing for ALT levels (3).

Publications

Pellett PE, et al. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43(9):1260-1268. DOI: 10.1046/j.1537-2995.2003.00490.x

Mariani R, et al. (1999) CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. (Translated from eng) J Virol 73(3):2450-2459. DOI: 10.1128/JVI.73.3.2450-2459.1999

Zuck TF, et al. (1995) The Retrovirus Epidemiology Donor Study (REDS): rationale and methods. (Translated from eng) Transfusion 35(11):944-951. DOI: 10.1046/j.1537-2995.1995.351196110900.x

Additional Details

Available Biospecimens

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Visits (Vials):

03/08/2021

	Serum	Plasma	Whole Blood	Total
Subjects with 1 Draw	238,045	101,668	202,663	542,376
Subjects with 2 Draws	31,860	26,452	53,958	112,270
Subjects with 3 Draws	6,338	8,812	18,275	33,425
Subjects with 4-10 Draws	2,978	5,897	12,544	21,419
Subjects with 11+ Draws	22	197	405	624

Visits (Subjects):

03/08/2021

	Serum
	Total number of subjects	Average volume (ml) per subject
Subjects with 1 Draw	218,948	2.12
Subjects with 2 Draws	30,596	2.07
Subjects with 3 Draws	6,126	2.06
Subjects with 4-10 Draws	1,717	3.46
Subjects with 11+ Draws	13	3.38

	Plasma
	Total number of subjects	Average volume (ml) per subject
Subjects with 1 Draw	100,259	1.51
Subjects with 2 Draws	26,293	1.51
Subjects with 3 Draws	8,776	1.50
Subjects with 4-10 Draws	3,982	2.22
Subjects with 11+ Draws	85	3.48

	Whole Blood
	Total number of subjects	Average volume (ml) per subject
Subjects with 1 Draw	104,159	0.99
Subjects with 2 Draws	27,484	1.00
Subjects with 3 Draws	9,264	1.02
Subjects with 4-10 Draws	4,163	1.58
Subjects with 11+ Draws	86	2.39

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Resources Available

Specimens Only

Study Catalog

Study Publications (18)

Materials Available

Plasma
Whole Blood
More Details

Study Documents

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