Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)

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Accession Number

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period

NHLBI Division

Primary Publication URLs


Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.


To provide researchers with an opportunity to conduct studies on a large representative sample of blood donors with linked demographic data and donation test results. Targeted investigations on particular subsets of the donor population are also feasible due to the availability of this linked data.


The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. One of the aims of this study is to establish blood specimen repositories for future testing. The General Leukocyte and Plasma Repository (GLPR) was established under this study.

The GLPR repository has already been used to investigate HHV-8 antibody prevalence in the US blood supply (1) and polymorphisms in chemokine receptor genes (2).


The GLPR was collected in 1994 and 1995 and consists of aliquots of plasma, and whole blood frozen, with or without DMSO, obtained from 147,915 blood donations.


Specimens for the GLPR repository were collected according to a statistical sampling plan, designed to obtain donations that are representative of all donor racial/ethnic groups. REDS blood centers that have contributed to the GLPR repository include: the American Red Cross (ARC) Greater Chesapeake and Potomac (Baltimore, MD; and Washington, DC), Southeastern Michigan (Detroit, MI), and Southern California (Los Angeles, CA) regions; the Blood Centers of the Pacific (BCP; San Francisco, CA); and the Oklahoma Blood Institute (Oklahoma City, OK).

Donor screening and testing was performed according to standard operating procedures and included tests for anti-HIV (types 1 and 2), anti-HCV, anti-HTLV, HBsAg and anti-HBc; serologic testing for syphilis and testing for ALT levels (3).


  1. Pellett PE, et al. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43(9):1260-1268. DOI: 10.1046/j.1537-2995.2003.00490.x

  2. Mariani R, et al. (1999) CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. (Translated from eng) J Virol 73(3):2450-2459. DOI: 10.1128/JVI.73.3.2450-2459.1999

  3. Zuck TF, et al. (1995) The Retrovirus Epidemiology Donor Study (REDS): rationale and methods. (Translated from eng) Transfusion 35(11):944-951. DOI: 10.1046/j.1537-2995.1995.351196110900.x

Additional Details

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Visits (Vials):

24 July 2023

Plasma Whole Blood Total
Subjects with 1 Draw 121,623 245,985 367,608
Subjects with 2 Draws 13,412 26,624 40,036
Subjects with 3 Draws 2,073 4,222 6,295
Subjects with 4-10 Draws 764 1,558 2,322
Visits (Subjects):

24 July 2023

Total number of subjects Average volume (ml) per subject
Subjects with 1 Draw 120,436 1.51
Subjects with 2 Draws 13,370 1.50
Subjects with 3 Draws 2,071 1.50
Subjects with 4-10 Draws 504 2.26
  Whole Blood
Total number of subjects Average volume (ml) per subject
Subjects with 1 Draw 126,993 0.99
Subjects with 2 Draws 13,532 1.01
Subjects with 3 Draws 2,104 1.05
Subjects with 4-10 Draws 509 1.60

Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.

Resources Available

Specimens Only

Materials Available

Study Documents

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