Skip to Main Content
U.S. Department of Health & Human Services » National Institutes of Health
National Heart, Lung, and Blood Institute
Login | Register

Biologic Specimen and Data Repository Information Coordinating Center

  • Home (current)
  • About BioLINCC
    • About Us
    • FAQ
    • Contact Us
    • Glossary
  • Biospecimen and Data Resources
    • Overview
    • Studies
    • Teaching Datasets - Public Use Datasets
    • Renew Existing Data Use Agreement
    • Publications
    • Funding Opportunities
    • Non-BioLINCC Resources
    • Covid-19 Resources
  • Procedures and Forms
    • BioLINCC Handbook
    • Form Templates
    • Agreement Templates
  • Build/Submit New Collection
    • Informed Consent Considerations
    • NHLBI Biorepository Guide
    • Submit Datasets
    • Submit Biospecimens and Datasets
Home > Studies > Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)

Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)

Note that you will be prompted to log in or register an account

Accession Number
HLB01890909a

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1994-1995

NHLBI Division
DBDR

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00005278

Primary Publication URLs
N/A

Consent

Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.

Objectives

To provide researchers with an opportunity to conduct studies on a large representative sample of blood donors with linked demographic data and donation test results. Targeted investigations on particular subsets of the donor population are also feasible due to the availability of this linked data.

Background

The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. One of the aims of this study is to establish blood specimen repositories for future testing. The General Leukocyte and Plasma Repository (GLPR) was established under this study.

The GLPR repository has already been used to investigate HHV-8 antibody prevalence in the US blood supply (1) and polymorphisms in chemokine receptor genes (2).

Subjects

The GLPR was collected in 1994 and 1995 and consists of aliquots of plasma, and whole blood frozen, with or without DMSO, obtained from 147,915 blood donations.

Design

Specimens for the GLPR repository were collected according to a statistical sampling plan, designed to obtain donations that are representative of all donor racial/ethnic groups. REDS blood centers that have contributed to the GLPR repository include: the American Red Cross (ARC) Greater Chesapeake and Potomac (Baltimore, MD; and Washington, DC), Southeastern Michigan (Detroit, MI), and Southern California (Los Angeles, CA) regions; the Blood Centers of the Pacific (BCP; San Francisco, CA); and the Oklahoma Blood Institute (Oklahoma City, OK).

Donor screening and testing was performed according to standard operating procedures and included tests for anti-HIV (types 1 and 2), anti-HCV, anti-HTLV, HBsAg and anti-HBc; serologic testing for syphilis and testing for ALT levels (3).

Publications



  1. Pellett PE, et al. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43(9):1260-1268. DOI: 10.1046/j.1537-2995.2003.00490.x




  2. Mariani R, et al. (1999) CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. (Translated from eng) J Virol 73(3):2450-2459. DOI: 10.1128/JVI.73.3.2450-2459.1999




  3. Zuck TF, et al. (1995) The Retrovirus Epidemiology Donor Study (REDS): rationale and methods. (Translated from eng) Transfusion 35(11):944-951. DOI: 10.1046/j.1537-2995.1995.351196110900.x



Additional Details

Available Biospecimens

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Visits (Vials):

03/08/2021

  Serum Plasma Whole Blood Total
Subjects with 1 Draw 238,045 101,668 202,663 542,376
Subjects with 2 Draws 31,860 26,452 53,958 112,270
Subjects with 3 Draws 6,338 8,812 18,275 33,425
Subjects with 4-10 Draws 2,978 5,897 12,544 21,419
Subjects with 11+ Draws 22 197 405 624

 
Visits (Subjects):

03/08/2021

  Serum
Total number of subjects Average volume (ml) per subject
Subjects with 1 Draw 218,948 2.12
Subjects with 2 Draws 30,596 2.07
Subjects with 3 Draws 6,126 2.06
Subjects with 4-10 Draws 1,717 3.46
Subjects with 11+ Draws 13 3.38
 
  Plasma
Total number of subjects Average volume (ml) per subject
Subjects with 1 Draw 100,259 1.51
Subjects with 2 Draws 26,293 1.51
Subjects with 3 Draws 8,776 1.50
Subjects with 4-10 Draws 3,982 2.22
Subjects with 11+ Draws 85 3.48
 
  Whole Blood
Total number of subjects Average volume (ml) per subject
Subjects with 1 Draw 104,159 0.99
Subjects with 2 Draws 27,484 1.00
Subjects with 3 Draws 9,264 1.02
Subjects with 4-10 Draws 4,163 1.58
Subjects with 11+ Draws 86 2.39

 

Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.

Resources Available

Specimens Only

Study Catalog

Study Publications (18)

Materials Available

  • Plasma
  • Whole Blood
  • More Details

Study Documents

  • PDF Data Dictionary (PDF - 25.5 KB)
  • PDF Database Information (PDF - 70.9 KB)
  • PDF Operations Manual (PDF - 34.7 MB)

Persons using assistive technology may not be able to fully access information in the study documents. For assistance, Contact BioLINCC and include the web address and/or publication title in your message. If you need help accessing information in different file formats such as PDF, XLS, DOC, see Instructions for Downloading Viewers and Players.

  • About Us
  • FAQ
  • Glossary
  • Contact
  • Privacy Policy
  • Accessibility
  • FOIA
  • HHS Vulnerability Disclosure

  • U.S. Department of Health & Human Services
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute
  • USA.gov
NIH… Turning Discovery Into Health®