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PDF Data Dictionary (PDF - 196.2 KB)

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NHLBI Umbilical Cord Blood Unit Collection (CBB)

Clinical Trials URL:
Study Type: Epidemiology Study
Prepared on August 24, 2009
Study Dates: 1998-2001
Consent: Restricted Consent
Consent Restrictions: Restrictions prohibit use for cell line production.
Commercial Use Restrictions: Yes
NHLBI Division: DBDR

The Cord Blood Units (CBU's) in this collection are considered anonymized. That is, the link to the CBU donor has been destroyed and only limited data are available to investigators (see Data Dictionary). Requestors of these CBU's must follow their institutional guidelines regarding the use of anonymized biospecimens. If IRB approval/waiver is not consistent with the requestor's institutional guidelines for the use of anonymized specimens, other institutional documentation or policy statements should be substituted to document research compliance.

Collection Type: Open BioLINCC Study - See bottom of this webpage for request information


The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.


Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.


The CBU were collected under standard operating procedures described in detail elsewhere (1) (


The CBU were collected under standard operating procedures described in detail elsewhere (1) (


J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).
M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).
J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).

Additional Details

Available Biospecimens

Visits (Vials):



Cord Blood Unit

One Draw per Subject


Visits (Subjects):



Cord Blood Unit

Total number of subjects

Average volume (ml) per subject

One Draw per Subject