NHLBI Umbilical Cord Blood Unit Collection (CBB)

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Accession Number
HLB01880909a

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1998-2001

NHLBI Division
DBDR

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00000603

Primary Publication URLs
https://www.ncbi.nlm.nih.gov/pubmed/15934981

Related Studies
COBLT

The Cord Blood Units (CBU's) in this collection are considered anonymized. That is, the link to the CBU donor has been destroyed and only limited data are available to investigators (see Data Dictionary). Requestors of these CBU's must follow their institutional guidelines regarding the use of anonymized biospecimens. If IRB approval/waiver is not consistent with the requestor's institutional guidelines for the use of anonymized specimens, other institutional documentation or policy statements should be substituted to document research compliance.

Consent

Commercial Use Specimen Restrictions Yes

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Restrictions prohibit the use of biospecimens for cell line production. A subset of biospecimens are available for infectious disease testing. Biospecimens are not available for commercial use.

Objectives

The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.

Background

Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.

Design

The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

Conclusions

The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

Specimen Notes

All COBLT CBUs are red cell depleted, volume reduced and cryopreserved with DMSO/Dextran in 25 ml bags.

Publications

J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).

M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).

J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).

Additional Details

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Visits (Vials):

11/01/2022

Subjects only have specimens from one time point.

  Cord Blood Aliquot Cord Blood Unit Total
Caucasian 1,977 185 2,162
Black/African 905 392 1,297
Asian/Pacific Islander 1,168 326 1,494
Hispanic 2,360 750 3,110
Other/Mixed 1,102 279 1,381
Visits (Subjects):

11/01/2022

Subjects only have specimens from one time point.

  Cord Blood Aliquot
Total number of subjects Average volume (ml) per subject
Caucasian 1,154 1.74
Black/African 466 1.96
Asian/Pacific Islander 596 1.99
Hispanic 1,425 1.68
Other/Mixed 571 1.96
 
  Cord Blood Unit
Total number of subjects Average bags per subject
Caucasian 185 1.00
Black/African 392 1.00
Asian/Pacific Islander 326 1.00
Hispanic 750 1.00
Other/Mixed 279 1.00

Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.

Resources Available

Specimens Only

Study Catalog

Study Publications (7)

Materials Available

Study Documents

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