NHLBI Umbilical Cord Blood Unit Collection (CBB) - Catalog

Name

NHLBI Umbilical Cord Blood Unit Collection (CBB)

Accession Number

HLB01880909a

Acronym

CBB

Related studies

(COBLT) Cord Blood Transplantation Study (COBLT)

BSI Study IDs

COBB

Is public use dataset

False

Keywords

Has Study Datasets

False

Has Specimens

True

Specimen ID Type

Anonymized

Study Website

The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

False

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00000603
Study type

Epidemiology Study

Collection Type

Open BioLINCC Study

Cohort type

Pediatric

Interventions

Procedure: stem cell transplantation

Study Open Date (Data)

None

Study Open Date (Specimens)

2009-10-01

Date materials available

2009-08-24

Last updated

None

Study period

1998-2001

Study Contacts
NHLBI Division

DBDR

Classification

Transfusion Medicine

HIV study classification

non-HIV

COVID study classification

non-COVID

Pre-Website # of Specimens Shipped

132

# of Returned Specimens

0

Primary Publication URLs
https://www.ncbi.nlm.nih.gov/pubmed/15934981
Conditions

Anemia, Aplastic
Fanconi Anemia
Hematologic Diseases
Hematopoietic Stem Cell Transplantation
Leukemia
Myelodysplastic Syndromes
Neoplasms
Severe Combined Immunodeficiency

Objectives

The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.

Background

Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.

Participants

Design

The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

Conclusions

The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

Disease classification

Publications

J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).

M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).

J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).

Mat types

Cord Blood Aliquot
Cord Blood Unit

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

  • Material Types
  • General Freeze/Thaw Status
  • Visits (Vials)

    11/01/2022

    Subjects only have specimens from one time point.

      Cord Blood Aliquot Cord Blood Unit Total
    Caucasian 1,977 185 2,162
    Black/African 905 392 1,297
    Asian/Pacific Islander 1,168 326 1,494
    Hispanic 2,360 750 3,110
    Other/Mixed 1,102 279 1,381

    Last Modified: Nov. 1, 2022, 1:55 p.m.
  • Visits (Subjects)

    11/01/2022

    Subjects only have specimens from one time point.

      Cord Blood Aliquot
    Total number of subjects Average volume (ml) per subject
    Caucasian 1,154 1.74
    Black/African 466 1.96
    Asian/Pacific Islander 596 1.99
    Hispanic 1,425 1.68
    Other/Mixed 571 1.96
     
      Cord Blood Unit
    Total number of subjects Average bags per subject
    Caucasian 185 1.00
    Black/African 392 1.00
    Asian/Pacific Islander 326 1.00
    Hispanic 750 1.00
    Other/Mixed 279 1.00

    Last Modified: Nov. 1, 2022, 1:55 p.m.