NHLBI Growth and Health Study (NGHS)

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Accession Number
HLB00270310a

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1985-2000

NHLBI Division
DCVS

Dataset(s) Last Updated
March 20, 2020

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00005132

Primary Publication URLs
N/A

Consent

Commercial Use Data Restrictions No

Data Restrictions Based On Area Of Research No

Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use No

Genetic Use Of Specimens Allowed? No

Genetic Use Area Of Research Restrictions No

Specific Consent Restrictions
None.

Objectives

To investigate racial differences in dietary, physical activity, family, and psychosocial factors associated with the development of obesity from pre-adolescence through maturation between African-American and white girls. Secondarily, the NGHS sought to examine the effects of obesity on cardiovascular disease risk factors.

Background

Obesity is a major contributing factor to several predictors of coronary heart disease such as hypertension, a poor lipid profile and diabetes. Both genetic and environmental factors play a significant role in the development of obesity, and there is evidence to suggest that obesity in childhood will likely carry over into adulthood. Prevention of obesity in early childhood could provide significant long term health benefits. A greater understanding of the factors contributing to childhood obesity is required for the establishment of effective weight reduction intervention programs. To this end, the National Growth and Health Study was initiated in 1985 as a multicenter study of the development of obesity among black and white pre-adolescent girls.

Participants

The NHLBI National Growth and Health Study recruited girls 9 and 10 years of age in two communities (Richmond, California and Cincinnati, Ohio) and also from families enrolled in a health maintenance organization in the Washington, D.C. area. A total of 2,379 girls were enrolled in the study between 1987-88 and were followed for 9 years. Slightly more than half of the cohort was African-American.

Design

Subjects had annual examinations, and data collected included: physical examination, anthropometric measurements, dietary information including food pattern and nutrient intake, physical activity, lipid, lipoprotein, and apolipoprotein profiles, family socioeconomic status, and psychosocial information.

Additional Details

Subjects:

2,379

Age:

 

Total Subjects

9

1,156

10

1,222

Unknown

1

Sex:

Female

Race:

 

Total Subjects

White

1,166

Black

1,213

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Material Types:

Serum

General Freeze/Thaw Status:

Serum - Majority unthawed

Visits (Vials):

04/16/2024

 

Serum

Total Vials

Unknown

245

245

Baseline

2,841

2,841

Year 3

4,091

4,091

Year 5

4,114

4,114

Year 7

3,579

3,579

Year 10

4,534

4,534

 

Visits (Subjects):

04/16/2024

 

Serum

Total number of subjects

Average volume (mL) per subject

Unknown

162

0.64

Baseline

2,542

0.53

Year 3

1,569

2.51

Year 5

1,379

3.27

Year 7

1,280

3.17

Year 10

1,300

1.50

 

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Resources Available

Specimens and Study Datasets

Study Catalog

Study Publications (35)

Materials Available

Study Documents

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