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Study Documents

PDF Data Dictionary (PDF - 1.2 MB)
PDF About HHP (PDF) - 112.5 KB
PDF Acculturation (PDF) - 182.8 KB
PDF Cognitive Function (PDF) - 670.3 KB
PDF Exam 1 (PDF) - 296.4 KB
PDF Exam 2 (PDF) - 297.2 KB
PDF Exam 3 (PDF) - 296.1 KB
PDF Exam 4 (PDF) - 1.2 MB
PDF Jenkins Physical Activity (PDF) - 148.0 KB
PDF Lipoproteins 1 (PDF) - 149.6 KB
PDF Lipoproteins 2 (PDF) - 231.3 KB
PDF Lipoproteins 3 (PDF) - 213.7 KB
PDF Morbidity Codebook (PDF) - 60.0 KB
PDF Mortality Codebook (PDF) - 56.2 KB
PDF Publication List (PDF) - 545.7 KB
PDF Surveillance Manual (PDF) - 355.9 KB

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Honolulu Heart Program (HHP)

Clinical Trials URL: http://clinicaltrials.gov/ct2/sh...
Study Type: Epidemiology Study
Prepared on October 13, 2008
Last Updated on June 23, 2005
Study Dates: 1965-1998
Consent: Unrestricted Consent
Commercial Use Restrictions: No
NHLBI Division: DCVS
Collection Type: Open BioLINCC Study - See bottom of this webpage for request information

Objectives

The initial objectives of the Honolulu Heart Program were to: 1) estimate morbidity and mortality from coronary heart disease and stroke among Japanese men in Honolulu; 2) compare morbidity and mortality from coronary heart disease and stroke among Japanese men in Japan, Honolulu, and San Francisco; 3) investigate relationships among risk factors, coronary heart disease, and stroke in Japanese men in Honolulu; 4) compare distributions of risk factors among men in Japan, Honolulu, and San Francisco, and relate similarities and differences in risk factors to the occurrence of disease in these areas and in other populations, including Framingham and Puerto Rico; 5) conduct an autopsy study, and to relate pathological findings to morbidity and mortality data; and 6) investigate relationships between risk factors and pathological evidence of atherosclerosis and its complications.

Background

The Honolulu Heart Program was initiated in 1965 by the NHLBI as a prospective study of environmental and biological causes of cardiovascular disease among Japanese Americans living in Hawaii. This population was known to have low incidence of coronary heart disease and higher incidence of stroke. The study provided opportunities to investigate relationships among disease frequencies, pathologic findings, and disease predictors in the cohort and to compare the findings in this population with those in other populations, especially cohorts of Japanese men resident in Japan or the U.S.

Subjects

American men of Japanese ancestry born in 1900-1919 and living on the island of Oahu in 1965; age at entry 28-62 years; sample size: 8,006.

Design

The study began in 1965 with the first examination of a cohort of 8,006 Japanese-American men residing on the island of Oahu, Hawaii who were born during the period 1900-1919. The first examination was completed in 1968 and was followed by the initiation of a second examination that same year. Three subsequent sub-examinations (Lipoprotein Exams I, II and III) were conducted between 1970 and 1982 to collect lipid measurements on a subset of those who participated in Exam 2. The fourth examination of surviving members of the original cohort was conducted during 1991-93 and collected data on 3,741 men. The National Institute on Aging conducted a fifth examination of approximately 3,400 survivors focusing on dementia and its precursors. This effort was concluded in 1996. Morbidity and mortality follow-up continues through grant and contract-supported efforts, and the current HHP dataset includes events through 1998.

Note:

The integrity and purity of the DNA has not been assessed by the NHLBI. Investigators interested in using DNA from this collection should submit an availability request to obtain additional information.

Additional Details

Study Population

Subjects:

8008

Age:

 

N

%

Missing

2

0.02

45 -< 50

1859

23.21

50 -< 55

2775

34.65

55 -< 60

1593

19.89

60 -< 65

1336

16.68

65 -< 70

443

5.53

Sex:

Male

Race:

Japanese-American

Available Biospecimens

Visits (Vials):

9/24/2015

 

Serum

Plasma

DNA

Total

Unknown

1,053

580

4,323

5,956

Examination 2

13,548

76

0

13,624

Examination 3

5,211

0

0

5,211

Examination 4

14,933

23,476

10,853

49,262

KS

2,946

0

0

2,946

Lipoproteins Examination 1

1,856

1,858

0

3,714

Lipoproteins Examination 2

6,949

0

0

6,949

Lipoproteins Examination 3

26

6,050

1

6,077

Visits (Subjects):

9/24/2015

 

Serum

Plasma

Total number of subjects

Average volume (ml) per subject

Total number of subjects

Average volume (ml) per subject

Unknown

489

9.93

575

0.87

Examination 2

2,778

3.72

32

4.27

Examination 3

5,207

1.85

0

0

Examination 4

3,500

3.88

3,614

5.54

KS

1,426

3.72

0

0

Lipoproteins Examination 1

1,398

5.71

1,059

3.86

Lipoproteins Examination 2

2,361

9.01

0

0

Lipoproteins Examination 3

22

1.61

1,738

3.42

 

 

DNA

Total number of subjects

Average mass (ug) per subject

Average vials per subject

Unknown

3,451

23.54

1.25

Examination 4

2,322

14.52

4.67

Lipoproteins Examination 3

1

0.80

1.00