NHLBI Umbilical Cord Blood Unit Collection (CBB)
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Accession Number
HLB01880909a
Study Type
Epidemiology Study
Collection Type
Open BioLINCC Study
See bottom of this webpage for request information
Study Period
1998-2001
NHLBI Division
DBDR
Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00000603
Primary Publication URLs
https://www.ncbi.nlm.nih.gov/pubmed/15934981
Related Studies
COBLT
The Cord Blood Units (CBU's) in this collection are considered anonymized. That is, the link to the CBU donor has been destroyed and only limited data are available to investigators (see Data Dictionary). Requestors of these CBU's must follow their institutional guidelines regarding the use of anonymized biospecimens. If IRB approval/waiver is not consistent with the requestor's institutional guidelines for the use of anonymized specimens, other institutional documentation or policy statements should be substituted to document research compliance.
Consent
Commercial Use Specimen Restrictions Yes
Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes
Genetic Use Of Specimens Allowed? Yes
Genetic Use Area Of Research Restrictions Yes
Specific Consent Restrictions
Restrictions prohibit the use of biospecimens for cell line production. A subset of biospecimens are available for infectious disease testing. Biospecimens are not available for commercial use.
Objectives
The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.
Background
Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.
Design
The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).
Conclusions
The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).
Specimen Notes
All COBLT CBUs are red cell depleted, volume reduced and cryopreserved with DMSO/Dextran in 25 ml bags.
Publications
J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).
M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).
J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).
Additional Details
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
Cord Blood Unit, Cord Blood Aliquot
Samples are unthawed
10/25/2024
Subjects only have specimens from one time point.
| Cord Blood Aliquot | Cord Blood Unit | Total Vials |
---|---|---|---|
Both Asian/Pacific Islander | 1,164 | 319 | 1,483 |
Both Black/African | 901 | 392 | 1,293 |
Both Caucasian | 1,973 | 177 | 2,150 |
Both Hispanic | 2,356 | 725 | 3,081 |
Other/Mixed | 1,102 | 262 | 1,364 |
10/25/2024
Subjects only have specimens from one time point.
| Cord Blood Aliquot | |
---|---|---|
Total number of subjects | Average volume (mL) per subject | |
Both Asian/Pacific Islander | 594 | 1.99 |
Both Black/African | 464 | 1.96 |
Both Caucasian | 1,152 | 1.74 |
Both Hispanic | 1,423 | 1.68 |
Other/Mixed | 571 | 1.96 |
| Cord Blood Unit | |
---|---|---|
Total number of subjects | Average bags per subject | |
Both Asian/Pacific Islander | 319 | 1.00 |
Both Black/African | 392 | 1.00 |
Both Caucasian | 177 | 1.00 |
Both Hispanic | 725 | 1.00 |
Other/Mixed | 262 | 1.00 |
Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.
Resources Available
Specimens OnlyMaterials Available
- Cord Blood Aliquot
- Cord Blood Unit
- More Details
Study Documents
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