Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study.
Pubmed ID: 29794966
Pubmed Central ID: PMC6024792
Publication Date: 05/24/2018
Affiliation: Department of Medicine Section of Preventative Medicine and Epidemiology, Boston University School of Medicine, Boston, MA 02118, USA. firstname.lastname@example.org.
MeSH Terms: Humans, Male, Adult, Female, Risk Factors, Middle Aged, Longitudinal Studies, Massachusetts, Proportional Hazards Models, Prognosis, Time Factors, Diabetes Mellitus, Type 2, Health Surveys, Blood Glucose, Cholesterol, Dietary, Biomarkers, Recommended Dietary Allowances, Diet, Healthy
Authors: Moore LL, Bradlee ML, Singer MR, Baghdasarian S, Lin HP, Pickering RT, Mott MM
Cite As: Baghdasarian S, Lin HP, Pickering RT, Mott MM, Singer MR, Bradlee ML, Moore LL. Dietary Cholesterol Intake Is Not Associated with Risk of Type 2 Diabetes in the Framingham Offspring Study. Nutrients 2018 May 24;10. (6).
Identification of diet and lifestyle risk factors for prevention of type 2 diabetes mellitus (T2DM) is of great importance. The specific role of dietary cholesterol (DC) in T2DM risk is unclear. This study uses data from 2192 Framingham Offspring Study subjects to estimate the effects of DC alone and in combination with markers of a healthy diet and other lifestyle factors on fasting glucose and risk of T2DM or impaired fasting glucose (IFG) over 20 years of follow-up. Dietary data were derived from two sets of three-day food records. Statistical methods included mixed linear regression and Cox proportional hazard's modeling to adjust for confounding. There were no statistically significant differences in glucose levels over 20 years of follow-up across DC intake categories (.