Framingham Heart Study-Offspring (FHS-OS)
Open BioLINCC Study See bottom of this webpage for request information
October 13, 2008
April 13, 2009
Clinical Trial URLs
Primary Publication URLs
Requestor's full or expedited IRB review is required for these data. Waivers are not accepted.
Commercial Use Data Restrictions Yes
Data Restrictions Based On Area Of Research No
Specific Consent Restrictions
Consent for use of data by commercial investigators is tiered.
Data available for request include Framingham Offspring examination data from the first 9 clinical exams, selected ancillary data and event follow-up through 2010. Also included are the first 4 exams from the OMNI 1 cohort.
The objectives of the Framingham Offspring Study are to study the incidence and prevalence of cardiovascular disease (CVD) and its risk factors, trends in CVD incidence and its risk factors over time, family patterns of CVD and risk factors. Less prominent but important objectives include the estimation of incidence rates of disease and description of the natural history of cardiovascular disease, including the sequence of clinical signs and systems that precede the clinically recognizable syndrome, and the consequences and course of clinically manifest disease.
With the aging of the Framingham cohort and with interest in familiar aggregation and heritability, a new cohort consisting of the offspring of the original cohort was sampled. Spouses of offspring were also included. This new sample, begun in 1971, constituted a second generation of participants, permitted new assessment of risk factors and outcomes, and provided a resource for the genetic analyses which were yet to come. The Offspring participants have had repeated examinations, though at longer intervals than the cohort.
5,124 men and women, ages 5-70 years at entry consisting of offspring of the original Framingham cohort (and spouses of the offspring) participated in the study.
By 1975, a sample of 5,124 men and women, consisting of offspring of the original Framingham cohort (and spouses of the offspring) had participated in the study. Additional studies of these subjects continued under research contracts. Participants have completed six examinations with intervals of four to six years and have been followed for morbidity and mortality over that time period.
The cardiovascular disease conditions under investigation include coronary heart disease (angina pectoris, myocardial infarction, coronary insufficiency and sudden and non-sudden death), stroke, hypertension, peripheral arterial disease and congestive heart failure.
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Resources AvailableStudy Datasets Only
- Data Dictionary (PDF - 5.3 MB)
- 30-Year Followup (Section 34) (PDF - 761.7 KB)
- Eye Exam Documentation (PDF - 792.0 KB)
- Framingham Eye Study II (FES II) Manual of Procedures (January 1988) (PDF - 1.3 MB)
- Data Coding Manuals
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