Framingham Heart Study-Offspring (FHS-OS)

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Prepared On
October 13, 2008

Last Updated
April 13, 2009

Study Dates
1971-

Consent
Unrestricted Consent

Commercial Restrictions
Yes

NHLBI Division
DCVS

Consent Restrictions
N/A

Clinical Trials URL
http://clinicaltrials.gov/ct2/sh...

Study Website
https://www.framinghamheartstudy...

Parent Study Contact
N/A

Requestor's full or expedited IRB review is required for these data. Waivers are not accepted.

Available Data

Data available for request include Framingham Offspring examination data from the first 9 clinical exams, selected ancillary data and event follow-up through 2010. Also included are the first 4 exams from the OMNI 1 cohort.

Objectives

The objectives of the Framingham Offspring Study are to study the incidence and prevalence of cardiovascular disease (CVD) and its risk factors, trends in CVD incidence and its risk factors over time, family patterns of CVD and risk factors. Less prominent but important objectives include the estimation of incidence rates of disease and description of the natural history of cardiovascular disease, including the sequence of clinical signs and systems that precede the clinically recognizable syndrome, and the consequences and course of clinically manifest disease.

Background

With the aging of the Framingham cohort and with interest in familiar aggregation and heritability, a new cohort consisting of the offspring of the original cohort was sampled. Spouses of offspring were also included. This new sample, begun in 1971, constituted a second generation of participants, permitted new assessment of risk factors and outcomes, and provided a resource for the genetic analyses which were yet to come. The Offspring participants have had repeated examinations, though at longer intervals than the cohort.

Subjects

5,124 men and women, ages 5-70 years at entry consisting of offspring of the original Framingham cohort (and spouses of the offspring) participated in the study.

Design

By 1975, a sample of 5,124 men and women, consisting of offspring of the original Framingham cohort (and spouses of the offspring) had participated in the study. Additional studies of these subjects continued under research contracts. Participants have completed six examinations with intervals of four to six years and have been followed for morbidity and mortality over that time period.

The cardiovascular disease conditions under investigation include coronary heart disease (angina pectoris, myocardial infarction, coronary insufficiency and sudden and non-sudden death), stroke, hypertension, peripheral arterial disease and congestive heart failure.

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Resources Available

Study Datasets Only

Study Publications (90)

Study Documents

Data Dictionary (PDF - 5.3 MB)
30-Year Followup (Section 34) (PDF) - 761.7 KB
Eye Exam Documentation (PDF) - 792.0 KB
Framingham Eye Study II (FES II) Manual of Procedures (January 1988) (PDF) - 1.3 MB

Data Coding Manuals

Forms

Protocols

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