NHLBI Umbilical Cord Blood Unit Collection (CBB) - Catalog
NHLBI Umbilical Cord Blood Unit Collection (CBB)
HLB01880909a
CBB
(COBLT) Cord Blood Transplantation Study (COBLT)
COBB
False
False
True
Anonymized
False
Epidemiology Study
Open BioLINCC Study
Pediatric
Procedure: stem cell transplantation
None
2009-10-01
2009-08-24
None
1998-2001
DBDR
Transfusion Medicine
non-HIV
non-COVID
132
0
Not Applicable (Specimens Only)
Not Applicable (Specimens Only)
Yes
Yes
Yes
Yes
Restrictions prohibit the use of biospecimens for cell line production. A subset of biospecimens are available for infectious disease testing. Biospecimens are not available for commercial use.
Anemia, Aplastic
Fanconi Anemia
Hematologic Diseases
Hematopoietic Stem Cell Transplantation
Leukemia
Myelodysplastic Syndromes
Neoplasms
Severe Combined Immunodeficiency
The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.
Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.
The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).
The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).
J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).
M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).
J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).
Cord Blood Aliquot
Cord Blood Unit
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
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Material Types
Cord Blood Unit, Cord Blood Aliquot
Last Modified: May 3, 2024, 11:02 a.m. -
General Freeze/Thaw Status
Samples are unthawed
Last Modified: May 3, 2024, 11:02 a.m. -
Visits (Vials)
10/25/2024
Subjects only have specimens from one time point.Cord Blood Aliquot
Cord Blood Unit
Total Vials
Both Asian/Pacific Islander
1,164
319
1,483
Both Black/African
901
392
1,293
Both Caucasian
1,973
177
2,150
Both Hispanic
2,356
725
3,081
Other/Mixed
1,102
262
1,364
Last Modified: Oct. 25, 2024, 2:51 p.m. -
Visits (Subjects)
10/25/2024
Subjects only have specimens from one time point.Cord Blood Aliquot
Total number of subjects
Average volume (mL) per subject
Both Asian/Pacific Islander
594
1.99
Both Black/African
464
1.96
Both Caucasian
1,152
1.74
Both Hispanic
1,423
1.68
Other/Mixed
571
1.96
Cord Blood Unit
Total number of subjects
Average bags per subject
Both Asian/Pacific Islander
319
1.00
Both Black/African
392
1.00
Both Caucasian
177
1.00
Both Hispanic
725
1.00
Other/Mixed
262
1.00
Last Modified: Oct. 25, 2024, 2:49 p.m.