NHLBI Umbilical Cord Blood Unit Collection (CBB) - Catalog

  • Name

    NHLBI Umbilical Cord Blood Unit Collection (CBB)

  • Accession Number

    HLB01880909a

  • Acronym

    CBB

  • Related studies
    (COBLT) Cord Blood Transplantation Study (COBLT)
  • BSI Study IDs

    COBB

  • Is public use dataset

    False

  • Keywords
  • Has Study Datasets

    False

  • Has Specimens

    True

  • Specimen ID Type
    Anonymized
  • Study Website
  • The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

    False

  • Clinical Trial URLs
    NCT00000603
  • Study type
    Epidemiology Study
  • Collection Type
    Open BioLINCC Study
  • Cohort type
    Pediatric
  • Interventions

    Procedure: stem cell transplantation

  • Study Open Date (Data)

    None

  • Study Open Date (Specimens)

    2009-10-01

  • Date materials available

    2009-08-24

  • Last updated

    None

  • Study period

    1998-2001

  • Study Contacts
  • NHLBI Division

    DBDR

  • Classification
    Transfusion Medicine
  • HIV study classification
    non-HIV
  • COVID study classification
    non-COVID
  • Pre-Website # of Specimens Shipped

    132

  • # of Returned Specimens

    0

  • Primary Publication URLs
    15934981
  • Commercial use data restrictions
    Not Applicable (Specimens Only)
  • Data restrictions based on area of research
    Not Applicable (Specimens Only)
  • Commercial use specimen restrictions
    Yes
  • Non-genetic use specimen restrictions based on area of use
    Yes
  • Genetic use of specimens allowed?
    Yes
  • Genetic use area of research restrictions
    Yes
  • Specific Consent Restrictions

    Restrictions prohibit the use of biospecimens for cell line production. A subset of biospecimens are available for infectious disease testing. Biospecimens are not available for commercial use.

  • Conditions
    Anemia, Aplastic
    Fanconi Anemia
    Hematologic Diseases
    Hematopoietic Stem Cell Transplantation
    Leukemia
    Myelodysplastic Syndromes
    Neoplasms
    Severe Combined Immunodeficiency
  • Objectives

    The NHLBI Umbilical Cord Blood Unit Collection parent study is the Cord Blood Transplantation Study Cord Blood Banking (COBLT CBB) program. The objective of the COBLT CBB was to build an ethnically diverse unrelated cord blood bank and to develop standard operating procedures for umbilical cord blood donor recruitment, selection and banking.

  • Background

    Cord blood is an alternative source of hematopoietic stem cells that has been shown to be efficacious in hematopoietic stem cell transplantation of both adults and pediatrics. Compared to other stem cell sources, cord blood is easier and safer to procure, has no donor attrition and can be stored and made readily available. Cord blood is rich in hematopoietic progenitor cells and antigen-inexperienced T cells. Transplantation of cord blood units are associated with reduced viral transmission, less acute and chronic graft-versus-host-disease than other stem cell sources. However, transplantation of cord blood also has been associated with delayed neutrophil and platelet engraftment, prolonged immune reconstitution, uncertain graft-versus-tumor activity, and cell doses from single cord blood units are a limiting factor for larger recipients.

  • Participants
  • Design

    The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

  • Conclusions

    The CBU were collected under standard operating procedures described in detail elsewhere (1) (https://web.emmes.com/study/cord/).

  • Disease classification
  • Publications

    J. K. Fraser et al., J Hematother 7, 521 (Dec, 1998).

    M. S. Cairo et al., Transfusion 45, 856 (Jun, 2005).

    J. Kurtzberg et al., Transfusion 45, 842 (Jun, 2005).

  • Mat types
    Cord Blood Aliquot
    Cord Blood Unit
  • Network

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. PDF Section 3.0 of the BioLINCC Handbook describes the components of the review process.

  • Material Types

    Cord Blood Unit, Cord Blood Aliquot


    Last Modified: May 3, 2024, 11:02 a.m.
  • General Freeze/Thaw Status

    Samples are unthawed


    Last Modified: May 3, 2024, 11:02 a.m.
  • Visits (Vials)

    10/25/2024

    Subjects only have specimens from one time point.

     

    Cord Blood Aliquot

    Cord Blood Unit

    Total Vials

    Both Asian/Pacific Islander

    1,164

    319

    1,483

    Both Black/African

    901

    392

    1,293

    Both Caucasian

    1,973

    177

    2,150

    Both Hispanic

    2,356

    725

    3,081

    Other/Mixed

    1,102

    262

    1,364


    Last Modified: Oct. 25, 2024, 2:51 p.m.
  • Visits (Subjects)

    10/25/2024

    Subjects only have specimens from one time point.

     

    Cord Blood Aliquot

    Total number of subjects

    Average volume (mL) per subject

    Both Asian/Pacific Islander

    594

    1.99

    Both Black/African

    464

    1.96

    Both Caucasian

    1,152

    1.74

    Both Hispanic

    1,423

    1.68

    Other/Mixed

    571

    1.96

     

     

    Cord Blood Unit

    Total number of subjects

    Average bags per subject

    Both Asian/Pacific Islander

    319

    1.00

    Both Black/African

    392

    1.00

    Both Caucasian

    177

    1.00

    Both Hispanic

    725

    1.00

    Other/Mixed

    262

    1.00


    Last Modified: Oct. 25, 2024, 2:49 p.m.