Thrombolysis in Myocardial Ischemia Trial III (TIMI III)

Note that you will be prompted to log in or register an account

Accession Number

Study Type
Clinical Trial

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period

NHLBI Division

Dataset(s) Last Updated
July 19, 2019

Primary Publication URLs


Commercial Use Data Restrictions No

Data Restrictions Based On Area Of Research No


Investigate the role of a thrombotic agent added to conventional medical therapies and to compare an early invasive management strategy to a more conservative early strategy in patients with unstable angina and non-Q wave myocardial infarction.


The myocardial ischemic syndromes, which account for a large portion of the annual mortality and morbidity from all causes in industrialized countries, encompass a wide clinical-pathologic spectrum. At one end of this spectrum are patients with chronic stable angina. When studied by coronary arteriography, such patients usually have obstructive atherosclerotic disease with no evidence of fresh thrombosis. At the other end of the spectrum are patients with acute MI who present with a discreet episode of prolonged chest pain accompanied by persistent ST segment elevation. Such patients have a high incidence of thrombotic coronary artery occlusion, and the early intravenous administration of thrombolytic agents has been shown to reestablish perfusion, limit the extent of left ventricular dysfunction, and reduce both early (in-hospital) and late (1-year) mortality in this group.


1,473 men and women enrolled through 25 participating centers. Ages ranged from 21 to 79 years; however, patients 75 to 79 years old were eligible for only a brief period during enrollment. Patients were required to have chest discomfort at rest suggestive of myocardial ischemia, lasting greater than 5 minutes but less than 6 hours, that occurred within 24 hours of the time of enrollment.


In a large study of unstable angina and non-Q wave myocardial infarction, the incidence of death and non-fatal infarction or reinfarction was low but not trivial after one year. An early invasive management strategy was associated with slightly more coronary angioplast procedures but equivalent numbers of bypass surgery procedures than a more conservative early strategy of catherization and revascularization only for signs of recurrent ischemia. The incidence of death or non-fatal infarction, or both, did not differ after one year by strategy assignment, but fewer patients in the early invasive strategy group underwent later repeat hospital admission. Either strategy is appropriate for patient management; differences in hospital admissions and revascularization procedures, with their attendant costs, are likely to be minimal.

Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.

Resources Available

Study Datasets Only

Study Documents

Persons using assistive technology may not be able to fully access information in the study documents. For assistance, Contact BioLINCC and include the web address and/or publication title in your message. If you need help accessing information in different file formats such as PDF, XLS, DOC, see Instructions for Downloading Viewers and Players.