Retrovirus Epidemiology Donor Study (REDS) HTLV Cohort (HTLV)

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Accession Number

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period

NHLBI Division

Dataset(s) Last Updated
January 3, 2018


Commercial Use Data Restrictions No

Data Restrictions Based On Area Of Research No


To conduct a longitudinal, multicenter epidemiologic study of the human retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II in volunteer blood donors from areas of the United States that were reportedly at high and medium or low risk for HIV.


Previous evidence suggested that human T-lymphotropic virus type II (HTLV-II) infection is associated with an increased incidence of bacterial infections.


The study includes 154 HTLV-I infected, 387 HTLV-II infected and 799 uninfected blood donors, all of whom were HIV type 1 seronegative at enrollment. Of the 1340 present and former blood donors examined at enrollment, 1213 (90.5%) were re-examined after approximately 2 years, including 136 HTLV-I and 337 HTLV-II seropositive subjects and 740 demographically stratified HTLV-seronegative subjects.


The data support an increased incidence of infectious diseases among otherwise healthy HTLV-II and HTLV-I infected subjects. They are also consistent with the lymphoproliferative effects of HTLV-I, and with neuropathic effects of HTLV-I and HTLV-II. (Arch Intern Med. 1999;159:1485-1491)

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Resources Available

Study Datasets Only

Study Documents

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