Retrovirus Epidemiology Donor Study (REDS) HTLV Cohort (HTLV)
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Open BioLINCC Study See bottom of this webpage for request information
October 13, 2008
January 24, 2008
Clinical Trial URLs
Primary Publication URLs
Commercial Use Data Restrictions No
Data Restrictions Based On Area Of Research No
To conduct a longitudinal, multicenter epidemiologic study of the human retroviruses HIV-1, HIV-2, HTLV-I, and HTLV-II in volunteer blood donors from areas of the United States that were reportedly at high and medium or low risk for HIV.
Previous evidence suggested that human T-lymphotropic virus type II (HTLV-II) infection is associated with an increased incidence of bacterial infections.
The study includes 154 HTLV-I infected, 387 HTLV-II infected and 799 uninfected blood donors, all of whom were HIV type 1 seronegative at enrollment. Of the 1340 present and former blood donors examined at enrollment, 1213 (90.5%) were re-examined after approximately 2 years, including 136 HTLV-I and 337 HTLV-II seropositive subjects and 740 demographically stratified HTLV-seronegative subjects.
The data support an increased incidence of infectious diseases among otherwise healthy HTLV-II and HTLV-I infected subjects. They are also consistent with the lymphoproliferative effects of HTLV-I, and with neuropathic effects of HTLV-I and HTLV-II. (Arch Intern Med. 1999;159:1485-1491)
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Resources AvailableStudy Datasets Only
- Data Dictionary (PDF - 1.5 MB)
- Analytic Database
- Phase 1 Documentation
- Phase 2 Documentation
- Phase 3 Documentation
- Phase 4 Documentation
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