Asthma Clinical Research Network (ACRN) Measuring Inhaled Corticosteroid Efficacy (MICE)
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Dataset(s) Last Updated
January 3, 2018
Clinical Trial URLs
Primary Publication URLs
Commercial Use Data Restrictions No
Data Restrictions Based On Area Of Research No
The purpose of this study was to compare the relative beneficial and systemic effects in a dose-response relationship for 2 ICSs.
A clinical model is needed to compare inhaled corticosteroids (ICS) with respect to efficacy.
30 asthmatic individuals 18 to 55 years of age. This was a feasibility study, not a comparative trial, therefore the sample size calculation was based on an appropriate sample size for estimating the common variance with some level of precision.
High-dose ICS therapy did not significantly increase the efficacy of measures that were evaluated but it did increase the systemic effect measure, overnight cortisol secretion.
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