Objectives

The NHLBI established the INHALD network in September of 2013 to investigate and define cellular and molecular events of HIV-associated lung diseases. The INHALD network is made up of eight clinical and basic research sites, and one data analysis and coordinating center. Each site is individually funded and has its own scientific aims, objectives, and protocols. The network includes two sites at the University of Colorado, Denver, Washington University, St. Louis, Johns Hopkins University, Massachusetts General Hospital, Indiana University, University of Louisville, Weill Medical College of Cornell University, and LAMDACC (Lung AIDS/HIV Mechanisms Data Analysis and Coordinating Center).

Background

Effective antiretroviral therapy regimens (ART) have resulted in the long-term survival of persons living with HIV (PLWH) and a rapidly expanding aging PLWH population. Infectious HIV-associated lung diseases (e.g., pneumonia and TB) and noninfectious HIV-related lung diseases (e.g., COPD and lung cancer) are much more prevalent in older individuals and are increasingly causes of morbidity and mortality. The pathogenesis of HIV-associated lung diseases and accelerated senescence of the lungs, which appear to be closely connected, are not well understood. As a result of these gaps in understanding, the ability to predict risk, provide accurate prognosis, and develop effective preventive or treatment therapies is lacking.

Participants

Each INHALD site developed inclusion/exclusion criteria based on their individual study objectives. An overall description of INHALD subjects includes:

Males and females (adult)
HIV-infected, HIV-uninfected
COPD, non-COPD
Current smokers, former smokers, non-smokers
ART-experienced, ART-naïve
PAH, non-PAH

Disease Classification

HIV infection
Chronic lung inflammation
Chronic Obstructive Pulmonary Disease
Pulmonary arterial hypertension
Emphysema
Redox stress

Design

Cross-sectional
Longitudinal

Publications

https://docs.google.com/document/d/1WkL0eFKxO2rUHey282_kf_3ZZnRU8zN5dFLI9Z9CEN4/edit?usp=sharing