Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)
Note that you will be prompted to log in or register an account
Accession Number
HLB01890909a
Study Type
Epidemiology Study
Collection Type
Open BioLINCC Study
See bottom of this webpage for request information
Study Period
1994-1995
NHLBI Division
DBDR
Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00005278
Primary Publication URLs
N/A
Consent
Commercial Use Specimen Restrictions No
Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes
Genetic Use Of Specimens Allowed? Yes
Genetic Use Area Of Research Restrictions Yes
Specific Consent Restrictions
Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.
Objectives
To provide researchers with an opportunity to conduct studies on a large representative sample of blood donors with linked demographic data and donation test results. Targeted investigations on particular subsets of the donor population are also feasible due to the availability of this linked data.
Background
The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. One of the aims of this study is to establish blood specimen repositories for future testing. The General Leukocyte and Plasma Repository (GLPR) was established under this study.
The GLPR repository has already been used to investigate HHV-8 antibody prevalence in the US blood supply (1) and polymorphisms in chemokine receptor genes (2).
Participants
The GLPR was collected in 1994 and 1995 and consists of aliquots of plasma, and whole blood frozen, with or without DMSO, obtained from 147,915 blood donations.
Design
Specimens for the GLPR repository were collected according to a statistical sampling plan, designed to obtain donations that are representative of all donor racial/ethnic groups. REDS blood centers that have contributed to the GLPR repository include: the American Red Cross (ARC) Greater Chesapeake and Potomac (Baltimore, MD; and Washington, DC), Southeastern Michigan (Detroit, MI), and Southern California (Los Angeles, CA) regions; the Blood Centers of the Pacific (BCP; San Francisco, CA); and the Oklahoma Blood Institute (Oklahoma City, OK).
Donor screening and testing was performed according to standard operating procedures and included tests for anti-HIV (types 1 and 2), anti-HCV, anti-HTLV, HBsAg and anti-HBc; serologic testing for syphilis and testing for ALT levels (3).
Publications
Pellett PE, et al. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43(9):1260-1268. DOI: 10.1046/j.1537-2995.2003.00490.x
Mariani R, et al. (1999) CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. (Translated from eng) J Virol 73(3):2450-2459. DOI: 10.1128/JVI.73.3.2450-2459.1999
Zuck TF, et al. (1995) The Retrovirus Epidemiology Donor Study (REDS): rationale and methods. (Translated from eng) Transfusion 35(11):944-951. DOI: 10.1046/j.1537-2995.1995.351196110900.x
Additional Details
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
24 July 2023
Plasma | ||
Total number of subjects | Average volume (ml) per subject | |
Subjects with 1 Draw | 120,436 | 1.51 |
Subjects with 2 Draws | 13,370 | 1.50 |
Subjects with 3 Draws | 2,071 | 1.50 |
Subjects with 4-10 Draws | 504 | 2.26 |
Whole Blood | ||
Total number of subjects | Average volume (ml) per subject | |
Subjects with 1 Draw | 126,993 | 0.99 |
Subjects with 2 Draws | 13,532 | 1.01 |
Subjects with 3 Draws | 2,104 | 1.05 |
Subjects with 4-10 Draws | 509 | 1.60 |
Please note that researchers must be registered on this site to submit a request, and you will be prompted to log in. If you are not registered on this site, you can do so via the Request button. Registration is quick, easy and free.
Resources Available
Specimens OnlyMaterials Available
- Plasma
- Whole Blood
- More Details
Study Documents
- Data Dictionary (PDF - 25.5 KB)
- Database Information (PDF - 70.9 KB)
- Operations Manual (PDF - 34.7 MB)
Persons using assistive technology may not be able to fully access information in the study documents. For assistance, Contact BioLINCC and include the web address and/or publication title in your message. If you need help accessing information in different file formats such as PDF, XLS, DOC, see Instructions for Downloading Viewers and Players.