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Home > Publications > The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus.

The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus.

Pubmed ID: 26212460

Journal: Heart & lung : the journal of critical care

Publication Date: 09/01/2015

Affiliation: Department of Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA.

MeSH Terms: Humans, Male, Adult, Female, Aged, Aged, 80 and over, Adolescent, Middle Aged, Body Mass Index, Diabetes Complications, Young Adult, Prognosis, Retrospective Studies, Obesity, Overweight, Obesity, Morbid, Respiratory Distress Syndrome

Authors: Chen W, Soubani AO, Jang H

Cite As: Soubani AO, Chen W, Jang H. The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus. Heart Lung 2015 Sep-Oct;44(5):441-7. Epub 2015 Jul 23.

Studies:

  • Acute Respiratory Distress Network (ARDSNet) Studies 01 and 03 Lower versus higher tidal volume, ketoconazole treatment and lisofylline treatment (ARMA/KARMA/LARMA)
  • Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA)
  • Acute Respiratory Distress Network (ARDSNet) Study 02 Late Steroid Rescue Study (LaSRS)
  • Acute Respiratory Distress Network (ARDSNet) Study 04 Assessment of Low tidal Volume and elevated End-expiratory volume to Obviate Lung Injury (ALVEOLI)
  • Acute Respiratory Distress Network (ARDSNet) Study 05 Fluid and Catheter Treatment Trial (FACTT)

Abstract

OBJECTIVE: To determine the 28 day mortality of patients with ARDS in relation to body mass index (BMI) and presence diabetes mellitus (DM). DESIGN: Retrospective cohort study of patients enrolled in the ARDS Network randomized controlled trials. RESULTS: 2914 patients were enrolled in these trials. 112 patients were underweight (BMI < 18.5), 948 patients were normal range (18.5 ≤ BMI < 25.0), 801 patients were overweight (25.0 ≤ BMI < 30.0), 687 patients were obese (30.0 ≤ BMI < 40.0), and 175 patients were severely obese (BMI ≥ 40.0). 469 patients had DM. There was no significant difference in the 28 day mortality in relation to BMI or presence of DM (underweight adjusted OR, 1.217; 95% CI, 0.749-1.979; overweight adjusted OR, 0.887; 95% CI, 0.696-1.131; obese adjusted OR, 0.812; 95% CI, 0.624-1.056; severely obese adjusted OR, 1.102; 95% CI, 0.716-1.695; and DM adjusted OR, 0.938; 95% CI, 0.728-1.208). CONCLUSIONS: The short term mortality in patients with ARDS is not affected by BMI or the presence of DM.

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