The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus.
Pubmed ID: 26212460
Journal: Heart & lung : the journal of critical care
Publication Date: 09/01/2015
Affiliation: Department of Oncology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA.
MeSH Terms: Humans, Male, Adult, Female, Aged, Aged, 80 and over, Adolescent, Middle Aged, Body Mass Index, Diabetes Complications, Young Adult, Prognosis, Retrospective Studies, Obesity, Overweight, Obesity, Morbid, Respiratory Distress Syndrome
Authors: Chen W, Soubani AO, Jang H
Cite As: Soubani AO, Chen W, Jang H. The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus. Heart Lung 2015 Sep-Oct;44(5):441-7. Epub 2015 Jul 23.
Studies:
- Acute Respiratory Distress Network (ARDSNet) Studies 01 and 03 Lower versus higher tidal volume, ketoconazole treatment and lisofylline treatment (ARMA/KARMA/LARMA)
- Acute Respiratory Distress Network (ARDSNet) Studies 06 and 08 Prospective, Randomized, Multicenter Trial of Aerosolized Albuterol Versus Placebo for the Treatment of Acute Lung Injury (ALTA)
- Acute Respiratory Distress Network (ARDSNet) Study 02 Late Steroid Rescue Study (LaSRS)
- Acute Respiratory Distress Network (ARDSNet) Study 04 Assessment of Low tidal Volume and elevated End-expiratory volume to Obviate Lung Injury (ALVEOLI)
- Acute Respiratory Distress Network (ARDSNet) Study 05 Fluid and Catheter Treatment Trial (FACTT)
Abstract
OBJECTIVE: To determine the 28 day mortality of patients with ARDS in relation to body mass index (BMI) and presence diabetes mellitus (DM). DESIGN: Retrospective cohort study of patients enrolled in the ARDS Network randomized controlled trials. RESULTS: 2914 patients were enrolled in these trials. 112 patients were underweight (BMI < 18.5), 948 patients were normal range (18.5 ≤ BMI < 25.0), 801 patients were overweight (25.0 ≤ BMI < 30.0), 687 patients were obese (30.0 ≤ BMI < 40.0), and 175 patients were severely obese (BMI ≥ 40.0). 469 patients had DM. There was no significant difference in the 28 day mortality in relation to BMI or presence of DM (underweight adjusted OR, 1.217; 95% CI, 0.749-1.979; overweight adjusted OR, 0.887; 95% CI, 0.696-1.131; obese adjusted OR, 0.812; 95% CI, 0.624-1.056; severely obese adjusted OR, 1.102; 95% CI, 0.716-1.695; and DM adjusted OR, 0.938; 95% CI, 0.728-1.208). CONCLUSIONS: The short term mortality in patients with ARDS is not affected by BMI or the presence of DM.