Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines.

Pubmed ID: 15776369

Journal: The Journal of infectious diseases

Publication Date: April 15, 2005

Affiliation: Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94121, USA. jarvis@itsa.ucsf.edu

MeSH Terms: Humans, Male, Adult, Female, Aged, Cohort Studies, Middle Aged, HTLV-II Infections, Time Factors, Antibody Affinity, Immunization, Immunoglobulin G, Least-Squares Analysis, Phagocytosis, Pneumococcal Vaccines, Streptococcus pneumoniae, Tetanus Toxoid

Grants: AI44103, AI48796, HL47114, HL62235, HL97078, HL97079, HL97080, HL97081, HL97082

Authors: Murphy EL, Jarvis GA, Janoff EN, Cheng H, Devita D, Fasching C, McCulloch CE

Cite As: Jarvis GA, Janoff EN, Cheng H, Devita D, Fasching C, McCulloch CE, Murphy EL. Human T lymphotropic virus type II infection and humoral responses to pneumococcal polysaccharide and tetanus toxoid vaccines. J Infect Dis 2005 Apr 15;191(8):1239-44. Epub 2005 Mar 14.

Studies:

Abstract

Infection with human T lymphotropic virus type II (HTLV-II) has been linked to an increased incidence of bacterial pneumonia. To determine whether HTLV-II infection is associated with impaired humoral immune responses, we immunized a cohort of HTLV-II-infected subjects and matched uninfected control subjects with 23-valent pneumococcal polysaccharide and tetanus toxoid vaccines. The pneumococcal polysaccharide vaccine elicited comparable and significant increases in concentrations of IgG against all 5 serotypes tested at 1 and 6 months after immunization in both groups. The avidity and opsonophagocytic functions of the anticapsular IgG were similar. The concentrations of tetanus toxoid-specific IgG also increased comparably and significantly over time in both groups. Thus, HTLV-II-infected persons develop robust humoral responses to potentially protective polysaccharide and protein vaccines.