An official website of the United States government
Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits.
Pubmed ID: 18794010
Pubmed Central ID: PMC2556901
Journal: Annals of epidemiology
Publication Date: Sept. 1, 2008
MeSH Terms: Humans, Male, Adult, Female, Aged, Aged, 80 and over, Aging, Middle Aged, Longitudinal Studies, Health Status Indicators, Population Surveillance, Epidemiologic Methods, Health Status
Grants: R01 AG028259, R01 AG027019, 1R01-AG-030612, 5P01-AG-008761, 5R01-AG-027019, 5R01-AG-028259, P01 AG008761, P01 AG008761-18, R01 AG027019-03, R01 AG028259-03, R01 AG030612, R01 AG030612-01, P30 AG034424, R03 HD050374
Authors: Yashin AI, Arbeev KG, Ukraintseva SV, Kulminski AM, Culminskaya IV, Land K
Cite As: Kulminski AM, Arbeev KG, Ukraintseva SV, Culminskaya IV, Land K, Yashin AI. Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits. Ann Epidemiol 2008 Sep;18(9):696-701.
Studies:
Abstract
PURPOSE: Health of the general population is improving along a number of major health dimensions. Using a cumulative deficits approach, we investigated whether such improvements were evident at the level of minor health traits. METHODS: We selected 37 small-effect traits consistently measured in the 9th (performed in 1964) and 14th (1974) Framingham Heart and 5th (1991-1995) Offspring Study exams to construct indices of cumulative deficits (DIs). RESULTS: We identified deficits-specific DIs characterizing health dimensions associated with no health changes (DI(NHC)), health worsening (DI(WRS)), and health improving (DI(IMP)) between the 1960s and 1990s. The risks of death attributable to the DI(NHC) dominate within shorter time horizons. For longer time horizons, both the DI(NHC) and DI(IMP) provide the same contribution to the risks of death. The mortality risks associated with the DI(WRS) are the weakest and least significant. CONCLUSIONS: The analyses show that the cumulative deficits approach might be an efficient tool for analyzing the effects of a large number of health characteristics for which the individual effects are small, inconsistent, or non-significant. They show favorable trends such that health of the Framingham studies participants either did not change or improved over time for the most serious small-effect traits.