Hyperuricemia and the echocardiographic measures of myocardial dysfunction.

Pubmed ID: 22587743

Journal: Congestive heart failure (Greenwich, Conn.)

Publication Date: May 1, 2012

Affiliation: Stanford University School of Medicine, Palo Alto, CA 94304, USA. e.krishnan@stanford.edu

MeSH Terms: Humans, Male, Female, Cohort Studies, Middle Aged, Longitudinal Studies, Heart Failure, Hyperuricemia, Uric Acid, Ventricular Dysfunction, Left, Echocardiography, Hypertrophy, Left Ventricular, Heart Ventricles

Authors: Krishnan E, Hariri A, Dabbous O, Pandya BJ

Cite As: Krishnan E, Hariri A, Dabbous O, Pandya BJ. Hyperuricemia and the echocardiographic measures of myocardial dysfunction. Congest Heart Fail 2012 May-Jun;18(3):138-43. Epub 2011 Oct 31.

Studies:

Abstract

Few studies have investigated the association between hyperuricemia and subclinical myocardial dysfunction. The authors analyzed the relationship between serum uric acid and subclinical markers of heart failure in participants in the Framingham Offspring Cohort (N=2169, mean age 57.3 years, 55.4% women). Cardiac dysfunction was assessed through echocardiographic measurements of left ventricular (LV) mass and thickness, end-diastolic LV thickness, and LV fractional shortening at the sixth visit, approximately 24 years after study onset. Participants in the highest serum uric acid quartile (≥ 6.2 mg/dL serum uric acid) had a significantly greater frequency of echocardiographic abnormalities compared with those in the lowest quartile (<4.3 mg/dL). Those in the highest quartile had multivariable-adjusted odds ratios of 9.013 (95% confidence interval, 2.051-39.604) for abnormal LV ejection fraction and 4.584 (95% confidence interval, 1.951-10.768) for LV systolic dysfunction compared with those in the lowest quartile. Hyperuricemia in young adults can be a marker for subsequent heart failure.