Natural progression of childhood asthma symptoms and strong influence of sex and puberty.
Pubmed ID: 24896645
Pubmed Central ID: PMC4213994
Journal: Annals of the American Thoracic Society
Publication Date: 07/01/2014
Affiliation: 1 Division of Research and Development, SoverST, LLC, Rockville, Maryland.
MeSH Terms: Humans, Male, Female, Risk Factors, United States, Adolescent, Sex Factors, Disease Progression, Child, Morbidity, Asthma, Child, Preschool, Puberty, Anti-Asthmatic Agents, Sexual Maturation
Grants: R01 MD007075, R01MD007075
Authors: Wang Z, Fu L, Freishtat RJ, Gordish-Dressman H, Teach SJ, Resca L, Hoffman EP
Cite As: Fu L, Freishtat RJ, Gordish-Dressman H, Teach SJ, Resca L, Hoffman EP, Wang Z. Natural progression of childhood asthma symptoms and strong influence of sex and puberty. Ann Am Thorac Soc 2014 Jul;11(6):939-44.
RATIONALE: Asthma prevalence, onset, remission and relapse, and healthcare use have been intensively studied. However, asthma symptom progression through childhood and adolescence has not been well studied, in part due to the challenges in obtaining consistent and robust long-term follow-up data on a large series of subjects with asthma. OBJECTIVES: To use the asthma diary symptom data of the Childhood Asthma Management Program placebo group (5 yr, 418 subjects, and total 564,518 records) to establish sex-specific high-resolution time courses of the natural progression of asthma symptoms through childhood and adolescence. METHODS: We used the asthma diary symptom code as a measure of daily disease severity. Annual records of Tanner stage were used to determine the influence of puberty on severity. A data alignment technique was used to derive 13-year time courses of mean symptoms and mean Tanner stage. MEASUREMENTS AND MAIN RESULTS: Data analyses showed three age- and sex-related phases of asthma symptom progression: Phase 1 (ages 5 and 6 yr)-greater severity in boys; Phase 2 (ages 7 to 9 yr)-no sex difference in severity; and Phase 3 (age 10-17 yr)-greater severity in girls. The continuous decline of symptoms in both sexes stops abruptly at the onset of puberty. CONCLUSIONS: The severity of asthma symptoms varies through childhood and adolescence, and patterns differ by sex. Puberty has a strong influence on symptom progression in both sexes. Progression of symptoms is a distinct aspect of asthma epidemiology.