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Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
Pubmed ID: 21258136
Pubmed Central ID: PMC3047140
Journal: Aging
Publication Date: Jan. 1, 2011
MeSH Terms: Humans, Longevity, Male, Female, Aged, Aged, 80 and over, Cardiovascular Diseases, Cohort Studies, Aging, Middle Aged, Blood Pressure, Research Design, Gait, Psychomotor Performance
Grants: AG-023629, AG-027058, N01 HC-55222, N01-HC-75150, N01-HC-85079, N01-HC-85086, N01 HC015103, N01 HC035129, N01 HC045133, N01 HC085084, N01 HC085085, N01HC55222, N01HC75150, N01HC85079, N01HC85086, R01 AG015928, R01 AG020098, R01 AG023629, R01 AG027058, U01 HL080295, 5K24AG025727, K24 AG025727, K24 AG025727-01A1, K24 AG025727-02, K24 AG025727-03, K24 AG025727-04, K24 AG025727-04S1, K24 AG025727-05, K24 AG025727-05S1, N01 HC055222, N01 HC075150, N01 HC085079, N01 HC085080, N01 HC085081, N01 HC085082, N01 HC085083, N01 HC085086, P30 AG024827, P30 AG024827-01, P30 AG024827-02, P30 AG024827-03, P30 AG024827-04, P30 AG024827-05, P30 AG024827-06, P30 AG024827-06S2, P30 AG024827-07, P30 AG024827-08, P30-AG-024827, R01 AG-15928, R01 AG-20098, R01 AG015928-02, R01 AG020098-01, R01 AG020098-02, R01 AG020098-03, R01 AG020098-04, R01 AG020098-05, R01 AG020098-06A2, R01 AG020098-07, R01 AG020098-08, R01 AG020098-09, R01 AG027058-01, R01 AG027058-02, R01 AG027058-03, R01 AG027058-04, R01 HL-075366, R01 HL075366, R01 HL075366-01A1, R01 HL075366-02, R01 HL075366-03, R01 HL075366-04, R01 HL075366-05, R56 AG023629, U01 AG023712, U01 AG023712-01, U01 AG023712-02, U01 AG023712-02S1, U01 AG023712-03, U01 AG023712-04, U01 AG023712-05, U01 AG023712-05S1, U01 AG023712-06, U01 AG023712-07, U01 AG023744, U01 AG023746, U01 AG023746-01, U01 AG023746-02, U01 AG023746-02S1, U01 AG023746-02S2, U01 AG023746-02S3, U01 AG023746-03, U01 AG023746-03S1, U01 AG023746-04, U01 AG023746-04S1, U01 AG023746-05, U01 AG023746-05S1, U01 AG023746-06, U01 AG023749, U01 AG023749-01, U01 AG023749-02, U01 AG023749-02S1, U01 AG023749-03, U01 AG023749-04, U01 AG023749-05, U01 AG023749-05S1, U01 AG023749-05S2, U01 AG023749-06, U01 AG023749-07, U01 AG023755, U01 AG023755-01, U01 AG023755-02, U01 AG023755-02S1, U01 AG023755-02S2, U01 AG023755-03, U01 AG023755-04, U01 AG023755-05, U01 AG023755-05S1, U01 AG023755-05S2, U01 AG023755-06, U01 AG023755-07, U01 HL080295-01, U01 HL080295-02, U01 HL080295-03, U01 HL080295-04, U01-AG023712, U01-AG023746, U01-AG023749, U01-AG023755, U01-AG23744, UL1 TR000005
Authors: Yashin AI, Christensen K, Hadley E, Lee JH, Sebastiani P, Newman AB, Glynn NW, Taylor CA, Perls TT, Mayeux R, Zmuda JM, Barral S, Simonsick EM, Walston JD
Cite As: Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging (Albany NY) 2011 Jan;3(1):63-76.
Studies:
Abstract
Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.