Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.

Pubmed ID: 28893868

Journal: The European respiratory journal

Publication Date: Sept. 11, 2017

MeSH Terms: Humans, Male, Adult, Female, Aged, Aged, 80 and over, Adolescent, Middle Aged, Young Adult, Child, Lung, Linear Models, Spirometry, Respiratory Function Tests, Child, Preschool, Reference Standards, International Cooperation, Carbon Monoxide, Pulmonary Diffusing Capacity, Societies, Medical, White People

Authors: Thompson B, Stanojevic S, Graham BL, Cooper BG, Thompson BR, Carter KW, Francis RW, Hall GL, Quanjer P, Stocks J, Marciniuk D, Ip MSM, Vazquez JC, Smith E, Zagami D, Kostianev S, Baden W, Michailopoulos P, Brusasco V, Kubota M, Gochicoa L, Arets H, van der Lee I, Collingwood A, Boros P, Ekerljung L, Young-Jee K, Zavorsky GS

Cite As: Stanojevic S, Graham BL, Cooper BG, Thompson BR, Carter KW, Francis RW, Hall GL, Global Lung Function Initiative TLCO working group, Global Lung Function Initiative (GLI) TLCO. Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians. Eur Respir J 2017 Sep 11;50. (3). Print 2017 Sep.

Studies:

Abstract

There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide (<i>T</i><sub> LCO</sub>); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values for <i>T</i><sub> LCO</sub>Data from 19 centres in 14 countries were collected to define <i>T</i><sub> LCO</sub> reference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R.12 660 <i>T</i><sub> LCO</sub> measurements from asymptomatic, lifetime nonsmokers were submitted; 85% of the submitted data were from Caucasians. All data were uncorrected for haemoglobin concentration. Following adjustments for elevation above sea level, gas concentration and assumptions used for calculating the anatomic dead space volume, there was a high degree of overlap between the datasets. Reference values for Caucasians aged 5-85 years were derived for <i>T</i><sub> LCO</sub>, transfer coefficient of the lung for carbon monoxide and alveolar volume.This is the largest collection of normative <i>T</i><sub> LCO</sub> data, and the first global reference values available for <i>T</i><sub> LCO</sub>.