Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study.

Pubmed ID: 29584578

Pubmed Central ID: PMC5984565

Journal: Metabolic syndrome and related disorders

Publication Date: June 1, 2018

Affiliation: 1 Department of Pediatrics, University of Virginia , Charlottesville, Virginia.

MeSH Terms: Humans, Male, Adult, Female, Cardiovascular Diseases, Aging, Adolescent, Longitudinal Studies, Sex Factors, Young Adult, Child, Alabama, Cross-Sectional Studies, Uric Acid, Diabetes Mellitus, Type 2, Insulin Resistance, Oxidative Stress, Metabolic Syndrome, Black People, White People

Grants: R01 HL120960

Authors: Wang LX, Filipp SL, Urbina EM, Gurka MJ, DeBoer MD

Cite As: Wang LX, Filipp SL, Urbina EM, Gurka MJ, DeBoer MD. Longitudinal Associations of Metabolic Syndrome Severity Between Childhood and Young Adulthood: The Bogalusa Heart Study. Metab Syndr Relat Disord 2018 Jun;16(5):208-214. Epub 2018 Mar 27.

Studies:

Abstract

BACKGROUND: Childhood metabolic syndrome (MetS) is associated with insulin resistance and increased risk for later development of type 2 diabetes (T2DM) and cardiovascular disease (CVD). In using MetS severity z-scores, our objective was to assess longitudinal associations in MetS severity, fasting insulin levels as a sign of insulin resistance and risk for T2DM, and uric acid levels as a biomarker of oxidative stress leading to CVD. METHODS: We used linear regression to analyze longitudinal data from 285 white and black participants from the Bogalusa Heart Study evaluated at baseline at ages 5-19 and as young adults after a mean of 12.0 years follow-up. We assessed correlations between childhood MetS severity and young-adult MetS severity, fasting insulin, and uric acid levels, both overall and by sex- and racial subgroups. RESULTS: Overall, childhood MetS z-scores were positively associated with young-adult MetS z-scores (r = 0.52), insulin (r = 0.34), and uric acid (r = 0.28) (all P < 0.001). These associations were consistent across all sex- and racial subgroups, except for young adult uric acid in white males in which childhood MetS-z was not associated (r = 0.15, P = 0.243). There was a strong cross-sectional association of young-adult MetS z-scores with insulin (r = 0.70) and uric acid (r = 0.57) (both P < 0.001), which was consistent for all sex- and racial subgroups. CONCLUSIONS: These positive longitudinal correlations between childhood MetS z-scores and markers of later insulin resistance and oxidative stress suggest long-term durability of risk for CVD and T2DM. This suggests potential for MetS severity to serve as an indicator to monitor for future risk of T2DM and CVD.