Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus.
Pubmed ID: 20102951
Pubmed Central ID: PMC2813214
Journal: The American journal of cardiology
Publication Date: 02/01/2010
Affiliation: Winters Center for Heart Failure Research and Section of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. firstname.lastname@example.org
MeSH Terms: Humans, Male, Female, Aged, Odds Ratio, Risk Factors, Cohort Studies, Middle Aged, Randomized Controlled Trials as Topic, Body Mass Index, Diabetes Complications, Heart Failure, Hospitalization, Confidence Intervals, Follow-Up Studies, Stroke Volume, Obesity, Medical Records, Research Design, Texas
Grants: K01 HL092585, 5K01-HL092585-02, K01 HL092585-01
Authors: Aguilar D, Ramasubbu K, Deswal A, Bozkurt B, Mann DL
Cite As: Aguilar D, Deswal A, Ramasubbu K, Mann DL, Bozkurt B. Comparison of patients with heart failure and preserved left ventricular ejection fraction among those with versus without diabetes mellitus. Am J Cardiol 2010 Feb 1;105(3):373-7. Epub 2009 Dec 22.
Heart failure (HF) with preserved left ventricular ejection fraction (LVEF) and diabetes commonly coexist, but the impact of diabetes on HF outcomes in patients with HF and preserved LVEF has not been well studied. We assessed the risk of HF death or hospitalization for worsening HF associated with diabetes by studying 987 patients with HF and preserved LVEF enrolled in the Digitalis Investigation Group (DIG) ancillary study. Diabetics (n = 285, 28.9%) were younger, had a larger body mass index, faster heart rate, and higher pulse pressure than nondiabetics. Diabetics were also more likely to be women, have a history of hypertension, ischemic cause for HF, and were more likely to be treated with diuretics. During the mean follow-up of 37 months, 88 (30.9%) diabetics and 133 (19.0%) nondiabetics developed the primary outcome of HF hospitalization or HF death. After adjustments for baseline differences, diabetes was associated with a 68% increased risk of HF hospitalization or HF death (adjusted hazard ratio 1.68, 95% confidence interval 1.26 to 2.25, p <0.001). In conclusion, in patients with HF and preserved LVEF, diabetes is associated with significantly increased risk of developing adverse HF outcomes.