Hematocrit and left ventricular mass: the Framingham Heart study.

Pubmed ID: 15063442

Journal: Journal of the American College of Cardiology

Publication Date: April 7, 2004

Affiliation: Division of Clinical Care Research, Department of Medicine, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

MeSH Terms: Humans, Male, Adult, Female, Middle Aged, Massachusetts, Sex Factors, Blood Pressure, Multivariate Analysis, Prospective Studies, Hematocrit, Sensitivity and Specificity, Echocardiography, Hypertrophy, Left Ventricular, Menopause, Statistics as Topic, Heart Ventricles, Biomarkers

Grants: K23 DK 02904, T32 HS00060

Authors: Tighiouart H, Weiner DE, Salem DN, Sarnak MJ, MacLeod B, Amin MG, Stark PC, Griffith JL

Cite As: Amin MG, Tighiouart H, Weiner DE, Stark PC, Griffith JL, MacLeod B, Salem DN, Sarnak MJ. Hematocrit and left ventricular mass: the Framingham Heart study. J Am Coll Cardiol 2004 Apr 7;43(7):1276-82.

Studies:

Abstract

OBJECTIVES: The goal of this study was to investigate the relationship between hematocrit (Hct) and left ventricular mass index (LVMI) and LV hypertrophy (LVH) in subjects without known hypertension or cardiovascular disease in the Framingham Heart study. BACKGROUND: Anemia may be an independent risk factor for cardiovascular disease in the general population. One potential explanation for this finding could be an association between Hct with LVMI or LVH. METHODS: Linear and logistic regression analyses were used to evaluate the association between Hct with LVMI and LVH. All analyses were stratified by gender and further according to menopausal status in women. RESULTS: There were 1,376 men and 1,769 women who met the inclusion criteria. The mean Hct and LVMI were 46.5% and 41.9%, and 127.3 and 95.8 g/m, respectively, in men and women. After adjustment for confounders, each 3% lower Hct was associated with a 2.6 g/m higher mean LVMI in men, and a 1.8 g/m higher mean LVMI in postmenopausal women (p < 0.05). There was a significant quadratic relationship between Hct and LVMI in premenopausal women (p < 0.01). Subjects in the lowest quartile of Hct (compared with the rest of the sample) had an adjusted odds ratio of LVH of 2.0 (95% confidence interval [CI] 1.3 to 3.0) in men and 1.4 (95% CI 0.8 to 2.4) in postmenopausal women. CONCLUSIONS: In a sample without known hypertension or cardiovascular disease, a lower Hct is associated with echocardiographically determined LVH in men and a small but significantly higher LVMI in men and postmenopausal women. The clinical importance of these findings remains unknown.