MicroRNAs in common human diseases.

Pubmed ID: 23200134

Pubmed Central ID: PMC3611977

Journal: Genomics, proteomics & bioinformatics

Publication Date: Oct. 1, 2012

Affiliation: Benaroya Research Institute and Center for Liver Disease, Digestive Disease Institute, Virginia Mason Medical Center, Seattle, WA 98101, USA. yli@benaroyaresearch.org

MeSH Terms: Humans, Animals, Neoplasms, MicroRNAs, Virus Diseases, Computational Biology, Immune System Diseases, Neurodegenerative Diseases

Grants: 1R21HL112678, 3R01DK056924-08S1, 5K24DK002957, K24 DK002957, R01 DK056924, R21 HL112678

Authors: Li Y, Kowdley KV

Cite As: Li Y, Kowdley KV. MicroRNAs in common human diseases. Genomics Proteomics Bioinformatics 2012 Oct;10(5):246-53. Epub 2012 Sep 29.

Studies:

Abstract

MicroRNAs (miRNAs) are a class of short non-coding RNA molecules that have attracted tremendous attention from the biological and biomedical research communities over the past decade. With over 1900 miRNAs discovered in humans to date, many of them have already been implicated in common human disorders. Facilitated by high-throughput genomics and bioinformatics in conjunction with traditional molecular biology techniques and animal models, miRNA research is now positioned to make the transition from laboratories to clinics to deliver profound benefits to public health. Herein, we overview the progress of miRNA research related to human diseases, as well as the potential for miRNA to becoming the next generation of diagnostics and therapeutics.