Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient Repository (RADAR) - Catalog

Name

Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient Repository (RADAR)

Accession Number

HLB01900909a

Acronym

REDS-RADAR

Related studies

BSI Study IDs

RAD

Is public use dataset

False

Keywords

Has Study Datasets

False

Has Specimens

True

Specimen ID Type

Coded

Study Website

The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

False

Clinical Trial URLs
https://clinicaltrials.gov/ct2/show/NCT00005278
Study type

Epidemiology Study

Collection Type

Open BioLINCC Study

Cohort type

Adult

Interventions

Study Open Date (Data)

None

Study Open Date (Specimens)

2009-10-01

Date materials available

2008-11-18

Last updated

None

Study period

2000-2003

Study Contacts
NHLBI Division

DBDR

Classification

Transfusion Medicine

HIV study classification

HIV-Related

COVID study classification

non-COVID

Pre-Website # of Specimens Shipped

31921

# of Returned Specimens

0

Primary Publication URLs
https://www.ncbi.nlm.nih.gov/pubmed/15987350
Conditions

Acquired Immunodeficiency Syndrome
Blood Donors
Blood Transfusion
HIV Infections
HIV-1
HIV-2
HTLV-I
HTLV-II
Retroviridae Infections

Objectives

Determine if newly identified or emerging pathogens can be transmitted by transfusion.

Background

Earlier repositories such as the NHLBI-sponsored Transfusion-Transmitted Virus Study (TTVS) and the National Institutes of Health Clinical Center repository were vital to the investigation of viral hepatitis transmission following blood transfusion. Based on the success of these collections it was determined that a more contemporary donor-recipient repository was needed. The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. In the late 1990's it was commissioned to establish a new linked donor-recipient repository.

Participants

A total of 127,864 donation specimens were collected from 101,197 different donors. The majority are not linked to any recipient specimens in the repository. The repository contains 13,201 donation specimens from 12,408 donors that were transfused into 3,575 recipients who completed the follow-up visit. Specimens consist of plasma (in most cases) or serum and frozen whole blood samples.

Design

The REDS Allogeneic Donor and Recipient (RADAR) repository was established between 2000 and 2003 by 5 REDS blood centers, 2 CDC-supported blood centers and eight collaborating hospitals with a wide US geographical distribution. Specimens from consented donors were collected, components from their donations were routed to participating hospitals, and recipients of these units consented to provide enrollment and follow-up specimens for long-term storage.

Conclusions

At the time of its completion, RADAR was the largest linked donor-recipient repository in the US. It was designed to be of sufficient size to study the transfusion transmissibility of emerging infectious agents.

Disease classification

Publications

Mat types

Plasma
Serum
Whole Blood

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

  • Material Types
  • General Freeze/Thaw Status
  • Visits (Vials)

    21Jul2023

     SerumPlasmaWhole BloodTotal
    Pre-Transfusion1,09313,0713,44117,605
    Post-Transfusion06,6801,5478,227
    6 Month Post Transfusion Follow-Up018,5513,53822,089
    Donor0263,996117,299381,295

     


    Last Modified: Oct. 12, 2023, 9:44 a.m.
  • Visits (Subjects)

    21Jul2023

     Serum
    Total number of subjectsAverage volume (ml) per subject
    Pre-Transfusion5952.42
     Plasma
    Total number of subjectsAverage volume (ml) per subject
    Donor92,8704.06
    Pre-Transfusion3,6602.98
    Post-Transfusion1,5563.35
    6 Month Post Transfusion Follow-Up3,5543.16
     Whole Blood
    Total number of subjectsAverage volume (ml) per subject
    Donor92,0101.85
    Pre-Transfusion3,4411.52
    Post-Transfusion1,5471.49
    6 Month Post Transfusion Follow-Up3,5371.49

    Last Modified: Oct. 12, 2023, 9:44 a.m.