Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient Repository (RADAR) - Catalog

  • Name

    Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient Repository (RADAR)

  • Accession Number

    HLB01900909a

  • Acronym

    REDS-RADAR

  • Related studies
  • BSI Study IDs

    RAD

  • Is public use dataset

    False

  • Keywords
  • Ingestion Status
    ---------
  • Has Study Datasets

    False

  • Has Specimens

    True

  • Specimen ID Type
    Coded
  • Study Website
  • The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

    False

  • Clinical Trial URLs
    NCT00005278
  • Study type
    Epidemiology Study
  • Collection Type
    Open BioLINCC Study
  • Cohort type
    Adult
  • Interventions
  • Study Open Date (Data)

    None

  • Study Open Date (Specimens)

    2009-10-01

  • Date materials available

    2008-11-18

  • Last updated

    None

  • Study period

    2000-2003

  • Study Contacts
  • NHLBI Division

    DBDR

  • Classification
    Transfusion Medicine
  • HIV study classification
    HIV-Related
  • COVID study classification
    non-COVID
  • Pre-Website # of Specimens Shipped

    31921

  • # of Returned Specimens

    0

  • Primary Publication URLs
    15987350
  • Commercial use data restrictions
    Not Applicable (Specimens Only)
  • Data restrictions based on area of research
    Not Applicable (Specimens Only)
  • Commercial use specimen restrictions
    No
  • Non-genetic use specimen restrictions based on area of use
    Yes
  • Genetic use of specimens allowed?
    Yes
  • Genetic use area of research restrictions
    Yes
  • Specific Consent Restrictions

    Some biospecimens are restricted to research related to transfusion safety and some biospecimens are not restricted.

  • Conditions
    Acquired Immunodeficiency Syndrome
    Blood Donors
    Blood Transfusion
    HIV Infections
    HIV-1
    HIV-2
    HTLV-I
    HTLV-II
    Retroviridae Infections
  • Objectives

    Determine if newly identified or emerging pathogens can be transmitted by transfusion.

  • Background

    Earlier repositories such as the NHLBI-sponsored Transfusion-Transmitted Virus Study (TTVS) and the National Institutes of Health Clinical Center repository were vital to the investigation of viral hepatitis transmission following blood transfusion. Based on the success of these collections it was determined that a more contemporary donor-recipient repository was needed. The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. In the late 1990's it was commissioned to establish a new linked donor-recipient repository.

  • Participants

    A total of 127,864 donation specimens were collected from 101,197 different donors. The majority are not linked to any recipient specimens in the repository. The repository contains 13,201 donation specimens from 12,408 donors that were transfused into 3,575 recipients who completed the follow-up visit. Specimens consist of plasma (in most cases) or serum and frozen whole blood samples.

  • Design

    The REDS Allogeneic Donor and Recipient (RADAR) repository was established between 2000 and 2003 by 5 REDS blood centers, 2 CDC-supported blood centers and eight collaborating hospitals with a wide US geographical distribution. Specimens from consented donors were collected, components from their donations were routed to participating hospitals, and recipients of these units consented to provide enrollment and follow-up specimens for long-term storage.

  • Conclusions

    At the time of its completion, RADAR was the largest linked donor-recipient repository in the US. It was designed to be of sufficient size to study the transfusion transmissibility of emerging infectious agents.

  • Disease classification
  • Publications
  • Mat types
    Plasma
    Serum
    Whole Blood
  • Network
    Retrovirus Epidemiology Donor Study I (REDS I)

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. PDF Section 3.0 of the BioLINCC Handbook describes the components of the review process.

  • Material Types

    Serum, Plasma, Whole Blood


    Last Modified: Jan. 27, 2025, 9:26 a.m.
  • General Freeze/Thaw Status
  • Visits (Vials)

    01/27/2025

     

    Plasma

    Whole Blood

    Serum

    Total Vials

    Donor

    90,345

    32,230

    .

    122,575

    Pre-Transfusion

    13,071

    3,441

    1,093

    17,605

    Post-Transfusion

    6,680

    1,547

    .

    8,227

    6 Month Post Transfusion Follow-Up

    18,551

    3,538

    .

    22,089


    Last Modified: Jan. 27, 2025, 9:35 a.m.
  • Visits (Subjects)

    01/27/2025

     

    Serum

    Total number of subjects

    Average volume (mL) per subject

    Pre-Transfusion

    595

    2.42

     

     

    Plasma

    Total number of subjects

    Average volume (mL) per subject

    Donor

    20,835

    5.03

    Pre-Transfusion

    3,660

    2.98

    Post-Transfusion

    1,556

    3.35

    6 Month Post Transfusion Follow-Up

    3,554

    3.16

     

     

    Whole Blood

    Total number of subjects

    Average volume (mL) per subject

    Donor

    20,371

    2.30

    Pre-Transfusion

    3,441

    1.52

    Post-Transfusion

    1,547

    1.49

    6 Month Post Transfusion Follow-Up

    3,537

    1.49


    Last Modified: Jan. 27, 2025, 9:34 a.m.