Prematurity-Related Ventilatory Control: Role in Respiratory Outcomes (Pre-Vent)

HLB03082626a

Pre-Vent

False

Obstetric Labor, Premature

Obstetric Labor Complications

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urogenital Diseases

Premature Birth

Released

True

True

Coded

False

Epidemiology Study

Open BioLINCC Study

Pediatric

2026-05-07

2026-05-07

2025-04-03

None

March 2018 – June 2021

DLD

Lung

non-HIV

non-COVID

None

None

No

Yes

No

Yes

Yes

Yes

Use of data and/or biospecimens is restricted to research related to breathing problems in infants

Infant, Premature
Prematurity

To develop a predictive model of short-term respiratory outcomes in extremely preterm infants, based on quantitative analysis of neonatal ICU cardiorespiratory monitoring data.

Preterm birth is a major cause of infant mortality and morbidity worldwide and a leading contributor to disability. Abnormal control of breathing is common in preterm infants and usually manifests as apnea, intermittent hypoxemia, bradycardia, and periodic breathing. Extremely preterm infants may also have impaired gas exchange caused by respiratory distress syndrome and subsequent bronchopulmonary dysplasia. The combination of apnea and lung disease often leads to more prolonged episodes of intermittent hypoxia. Such chronic intermittent hypoxia is associated with worse short-term outcomes (e.g., increased respiratory support, retinopathy of prematurity) and neurodevelopmental impairment that are difficult to predict in the neonatal ICU (NICU). The contribution of abnormal control of breathing to respiratory outcomes has not been determined. The Pre-Vent study was initiated to analyze cardiorespiratory continuous waveform monitoring data to delineate mechanisms of immature ventilatory control in preterm infants and identify predictive markers.

Infants less than 29 weeks gestational age with continuously archived cardiorespiratory monitoring data were included. 717 total infants were evaluated.

Pre-Vent was an observational multicenter prospective cohort study. Clinical data collected included respiratory support, medications, and co-morbidity data. Physiologic data consisted of variables extracted from cardiorespiratory monitoring data and quantified by count of events per day and duration per event. The extracted variables were apnea (≥20 seconds), periodic breathing (wavelet transform using a five-breath template), intermittent hypoxia events with oxygen saturation <80% as measured by pulse oximetry, intermittent hypoxia events with oxygen saturation <90% as measured by pulse oximetry, and bradycardia (<80bpm for 5 seconds or longer).

Infants discharged prior to 40 weeks post-menstrual age or inpatient infants at 40 weeks post-menstrual age had a favorable outcome if they were not on respiratory support or respiratory medications. Infants discharged prior to 40 weeks post-menstrual age or inpatient infants at 40 weeks post-menstrual age had an unfavorable outcome if they were on respiratory medications and/or respiratory support, or deceased.

The major findings of this study were that mathematical models based on cardiorespiratory bedside monitoring can identify alterations in physiologic measures that are independently associated with unfavorable respiratory outcomes in extremely preterm infants. Both physiologic and clinical variables contributed to good prediction models, with the contribution by physiologic variables increasing with postnatal age.

Weese-Mayer DE, Di Fiore JM, Lake DE, et al. Maturation of cardioventilatory physiological trajectories in extremely preterm infants. Pediatr Res. 2024;95(4):1060-1069. doi:10.1038/s41390-023-02839-0

Ambalavanan N, Weese-Mayer DE, Hibbs AM, et al. Cardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants. Am J Respir Crit Care Med. 2023;208(1):79-97. doi:10.1164/rccm.202210-1971OC

DNA