Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI Heart) - Catalog
Optimal Macronutrient Intake Trial to Prevent Heart Disease (OMNI Heart)
HLB00831119a
OMNI Heart
OHS
False
True
True
Coded
False
Clinical Trial
Open BioLINCC Study
Adult
Behavioral: Diet therapy
2011-07-06
2011-07-06
2010-03-04
None
2002 - 2008
DCVS
Heart
non-HIV
non-COVID
2075
0
No
No
No
Yes
No
Not Applicable (No Genetic Use Specimens)
Consent restricts use of biospecimens to non-genetic research related to CVD or nutrition.
Atherosclerosis
Cardiovascular Diseases
Heart Diseases
Hypertension
The objective of this study was to compare the effects of 3 healthy diets, each with reduced saturated fat intake, on blood pressure and serum lipids.
While reduced intake of saturated fat is widely recommended for the prevention of cardiovascular disease (CVD), the type of macronutrient (carbohydrate, protein, or unsaturated fat) that should replace saturated fat was unresolved.
The trial included 164 total subjects recruited from 2 clinical centers: Johns Hopkins Medical Institutions (Baltimore, MD) and Brigham and Women’s Hospital (Boston, MA). Subjects were generally healthy adults, age ≥30 years with a systolic blood pressure (SBP) 120-159 mm Hg or diastolic blood pressure (DBP) 80-99 mm Hg. This range includes individuals with prehypertension (systolic, 120-139 mm Hg or diastolic, 80-89 mm Hg) and stage 1 hypertension (systolic, 140-159 mm Hg or diastolic, 90-99 mm Hg). Exclusion criteria included diabetes, prior or active CVD, LDL-cholesterol >220 mg/dL, fasting triglycerides >750 mg/dL, weight more than 350lb, taking medication for reduction of blood pressure lipid levels, unwillingness to stop taking vitamin and mineral supplements, and alcoholic intake of more than 14 drinks per week. The mean age of the participants was 53.6 years, 45% were women, and 55% were African American.
Three healthy diets were tested: a carbohydrate-rich diet similar to the DASH diet, a protein rich diet−about half from plants, and a diet rich in unsaturated fat, mostly monosaturated fat. Subjects spent 3 periods of 6 weeks on each diet. There was 2-4 week washout periods in between the diets−subjects ate their own food during these periods. At the beginning of the study there was a run-in period of 6 days, afterwards the subjects were randomized to 1 of the 6 sequences of the 3 diets. All the food during the study was provided by the researchers. The participants came to the study site weekdays for lunch and food for the other two daily meals, snacks, and weekend meals were provided for the participants to take home. Calories were adjusted in order to maintain weight and to avoid confounding effects of weight loss in the study. Potassium and sodium were also maintained during the study.
A healthy diet with partial substitution of carbohydrate with either protein or monosaturated fat can further lower blood pressure, improve lipid levels, and reduce estimated cardiovascular risk.
Appel LJ, Sacks FM, Carey VJ, Obarzanek E, Swain JF, Miller ER 3rd, Conlin PR, Erlinger TP, Rosner BA, Laranjo NM, Charleston J, McCarron P, Bishop LM; OmniHeart Collaborative Research Group. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA. 2005 Nov 16;294(19):2455-64.
Furtado JD, Campos H, Sumner AE, Appel LJ, Carey VJ, Sacks FM. Dietary interventions that lower lipoproteins containing apolipoprotein C-III are more effective in whites than in blacks: results of the OmniHeart trial. Am J Clin Nutr. 2010 Oct;92(4):714-22. Epub 2010 Sep 8.
Plasma
Serum
Urine
The study population available in BioLINCC study data may be lower than total study enrollment due to Informed Consent restrictions and other factors.
-
Subjects
164
Last Modified: July 28, 2014, 1:44 p.m. -
Age
Frequency
Percent
26-30
3
1.83
31-35
9
5.49
36-40
9
5.49
41-45
13
7.93
46-50
34
20.73
51-55
28
17.07
56-60
29
17.68
61-65
17
10.37
66-70
16
9.76
71-75
2
1.22
76-80
4
2.44
Last Modified: June 22, 2022, 1:11 p.m. -
Sex
Frequency
Percent
Male
91
55.49
Female
73
44.51
Last Modified: June 22, 2022, 1:11 p.m. -
Race
Frequency
Percent
African American
90
54.88
Non-African American
74
45.12
Last Modified: June 22, 2022, 1:11 p.m.
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
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Material Types
Last Modified: Nov. 30, 2015, 2:06 p.m. -
General Freeze/Thaw Status
-
Visits (Vials)
06/22/2022
Last Modified: June 22, 2022, 1:11 p.m. -
Visits (Subjects)
06/22/2022
Plasma Total number of subjects Average volume (ml) per subject Screening Visit 3 161 2.12 Intervention Period 1 Week 4 162 6.68 Intervention Period 1 Week 6 162 2.07 Intervention Period 2 Week 4 162 6.65 Intervention Period 2 Week 6 161 2.09 Intervention Period 3 Week 4 157 6.48 Intervention Period 3 Week 6 157 2.03 Urine Total number of subjects Average volume (ml) per subject Screening Visit 3 143 6.12 Intervention Period 1 Week 6 154 5.89 Intervention Period 2 Week 6 157 5.98 Intervention Period 3 Week 6 150 6.08
Last Modified: June 22, 2022, 1:11 p.m.