Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR) - Catalog

  • Name

    Retrovirus Epidemiology Donor Study (REDS) General Leukocyte/Plasma Repository (GLPR)

  • Accession Number

    HLB01890909a

  • Acronym

    REDS-GLPR

  • Related studies
  • BSI Study IDs

    RD2

  • Is public use dataset

    False

  • Keywords
  • Ingestion Status
    ---------
  • Has Study Datasets

    False

  • Has Specimens

    True

  • Specimen ID Type
    Coded
  • Study Website
  • The Framingham Heart Study Group requires that the requestor must obtain full or expedited IRB/Ethics Committee review and approval to obtain these data. Waivers or a determination that the research is exempt from ethical regulations do not suffice.

    False

  • Clinical Trial URLs
    NCT00005278
  • Study type
    Epidemiology Study
  • Collection Type
    Open BioLINCC Study
  • Cohort type
    Adult
  • Interventions
  • Study Open Date (Data)

    None

  • Study Open Date (Specimens)

    2009-10-01

  • Date materials available

    2009-09-02

  • Last updated

    2021-11-04

  • Study period

    1994-1995

  • Study Contacts
  • NHLBI Division

    DBDR

  • Classification
    Transfusion Medicine
  • HIV study classification
    HIV-Related
  • COVID study classification
    non-COVID
  • Pre-Website # of Specimens Shipped

    60779

  • # of Returned Specimens

    62310

  • Primary Publication URLs
    N/A
  • Commercial use data restrictions
    Not Applicable (Specimens Only)
  • Data restrictions based on area of research
    Not Applicable (Specimens Only)
  • Commercial use specimen restrictions
    No
  • Non-genetic use specimen restrictions based on area of use
    Yes
  • Genetic use of specimens allowed?
    Yes
  • Genetic use area of research restrictions
    Yes
  • Specific Consent Restrictions

    Some biospecimens are restricted to research related to transfusion safety. Some biospecimens are not restricted.

  • Conditions
    Acquired Immunodeficiency Syndrome
    Blood Donors
    Blood Transfusion
    HIV Infections
    HIV-1
    HIV-2
    HTLV-I
    HTLV-II
    Retroviridae Infections
  • Objectives

    To provide researchers with an opportunity to conduct studies on a large representative sample of blood donors with linked demographic data and donation test results. Targeted investigations on particular subsets of the donor population are also feasible due to the availability of this linked data.

  • Background

    The Retrovirus Epidemiology Donor Study (REDS) has been conducted since 1989. One of the aims of this study is to establish blood specimen repositories for future testing. The General Leukocyte and Plasma Repository (GLPR) was established under this study.


    The GLPR repository has already been used to investigate HHV-8 antibody prevalence in the US blood supply (1) and polymorphisms in chemokine receptor genes (2).

  • Participants

    The GLPR was collected in 1994 and 1995 and consists of aliquots of plasma, and whole blood frozen, with or without DMSO, obtained from 147,915 blood donations.

  • Design

    Specimens for the GLPR repository were collected according to a statistical sampling plan, designed to obtain donations that are representative of all donor racial/ethnic groups. REDS blood centers that have contributed to the GLPR repository include: the American Red Cross (ARC) Greater Chesapeake and Potomac (Baltimore, MD; and Washington, DC), Southeastern Michigan (Detroit, MI), and Southern California (Los Angeles, CA) regions; the Blood Centers of the Pacific (BCP; San Francisco, CA); and the Oklahoma Blood Institute (Oklahoma City, OK).


    Donor screening and testing was performed according to standard operating procedures and included tests for anti-HIV (types 1 and 2), anti-HCV, anti-HTLV, HBsAg and anti-HBc; serologic testing for syphilis and testing for ALT levels (3).

  • Conclusions
  • Disease classification
  • Publications


    1. Pellett PE, et al. (2003) Multicenter comparison of serologic assays and estimation of human herpesvirus 8 seroprevalence among US blood donors. Transfusion 43(9):1260-1268. DOI: 10.1046/j.1537-2995.2003.00490.x




    2. Mariani R, et al. (1999) CCR2-64I polymorphism is not associated with altered CCR5 expression or coreceptor function. (Translated from eng) J Virol 73(3):2450-2459. DOI: 10.1128/JVI.73.3.2450-2459.1999




    3. Zuck TF, et al. (1995) The Retrovirus Epidemiology Donor Study (REDS): rationale and methods. (Translated from eng) Transfusion 35(11):944-951. DOI: 10.1046/j.1537-2995.1995.351196110900.x



  • Mat types
    Plasma
    Whole Blood
  • Network
    Retrovirus Epidemiology Donor Study I (REDS I)

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. PDF Section 3.0 of the BioLINCC Handbook describes the components of the review process.

  • Material Types
  • General Freeze/Thaw Status
  • Visits (Vials)

    24 July 2023
     

    Plasma Whole Blood Total
    Subjects with 1 Draw 121,623 245,985 367,608
    Subjects with 2 Draws 13,412 26,624 40,036
    Subjects with 3 Draws 2,073 4,222 6,295
    Subjects with 4-10 Draws 764 1,558 2,322

    Last Modified: July 24, 2023, 9:35 a.m.
  • Visits (Subjects)

    24 July 2023

    Plasma
    Total number of subjects Average volume (ml) per subject
    Subjects with 1 Draw 120,436 1.51
    Subjects with 2 Draws 13,370 1.50
    Subjects with 3 Draws 2,071 1.50
    Subjects with 4-10 Draws 504 2.26
     
      Whole Blood
    Total number of subjects Average volume (ml) per subject
    Subjects with 1 Draw 126,993 0.99
    Subjects with 2 Draws 13,532 1.01
    Subjects with 3 Draws 2,104 1.05
    Subjects with 4-10 Draws 509 1.60

    Last Modified: July 24, 2023, 9:35 a.m.