Transfusion-Transmitted Viruses Study (TTVS)

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Accession Number
HLB01910909a

Study Type
Epidemiology Study

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1974-1980

NHLBI Division
DBDR

Clinical Trial URLs
N/A

Primary Publication URLs
N/A

Related Studies
NANB-TAH

Consent

Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Consent for both genetic and non-genetic use of biospecimens is restricted to studies involving transfusion safety.

Objectives

To establish a repository of specimens collected from prospectively identified cases of non-A, non-B (NANB) hepatitis after blood transfusion. The major intentions were to determine the incidence of that occurrence, identify the characteristics of the donors associated with the event, and have a resource available to compare laboratory donor screening methods during the study and in subsequent years following completion of the study.

Background

From July 1974 through June 1980, the TTVS group prospectively identified cases of NANB hepatitis in a cohort of 1,533 transfused patients hospitalized short-term for various routine operative procedures. The TTVS collection has been used in a variety of studies, such as the evaluation and validation of Hepatitis C Virus (HCV) immunoassays in screening blood donors (1). In addition, specimens have been requested to evaluate poorly characterized hepatotropic viruses, transmissibility of new viruses (hepatitis G, HHV-8) by transfusion, and the dynamics of HBV/HCV viral replication and seroconversion in recipients.

Participants

Serum specimens from 5,655 blood donors were collected from 4 participating blood centers distributed across the US. 3,121 patients were consented to participate in a study of viral hepatitis after blood transfusion. The majority of patients were scheduled for elective surgery. Of these subjects, 1,533 subsequently received blood transfusions. Both transfusion recipients and control subjects that did not require transfusion were observed and blood was collected prior to surgery or pre-transfusion and again during visits at 2-3 week intervals during the first 6 months following the transfusion episode and again between 8-10 months.

A subset of this cohort was subsequently recruited into the Natural History Study of Non-A, Non-B Post Transfusion Hepatitis (NANB-TAH) that also has data and biospecimens available. Subjects cannot be linked between these two studies.

Design

The collection originally consisted of aliquots of serum acquired at patient observation visits and from the collection agency for every donor to each TTVS recipient. These sera included the pre-transfusion or pre-surgical specimen, all interval blood draws from these patients and the non-transfused control patients, a specimen from the donor at the time of blood collection and in a subpopulation of donors a follow-up specimen from donors implicated in suspected cases of transfusion transmitted hepatitis and a matched set of non-implicated donors.

Conclusions

The TTVS collection provides sera from a large transfusion donor-recipient study in which an untransfused control population with reasonably matched characteristics and of adequate size is available.

Publications


  1. Mosley JW, et al. (1990) Non-A, non-B hepatitis and antibody to hepatitis C virus. JAMA 263(1):77-78.

Additional Details

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Visits (Vials):

12/06/2018

 SerumPlasma or SerumTotal
Recipient Visit 111,04699312,039
Recipient Visit 26,255216,276
Recipient Visit 312,4643312,497
Recipient Visit 411,0948811,182
Recipient Visit 57,0672967,363
Recipient Visit 69,36977810,147
Recipient Visit 75,8882036,091
Recipient Visit 86,8812897,170
Recipient Visit 99,1267009,826
Recipient Visit 106,3502486,598
Recipient Visit 117,2753097,584
Recipient Visit 127,6015958,196
Recipient Visit 133,9451704,115
Recipient Visit 141,816511,867
Recipient Visit 151,071281,099
Recipient Visit 1676520785
Recipient Visit 1767713690
Recipient Visit 1855314567
Recipient Visit 195098517
Recipient Visit 204077414
Recipient Visit 213293332
Recipient Visit 222475252
Recipient Visit 231930193
Recipient Visit 241982200
Recipient Visit 251561157
Recipient Visit 2696096
Recipient Visit 2784084
Recipient Visit 2880080
Recipient Visit 2980080
Recipient Visit 3059059
Recipient Visit 3160060
Recipient Visit 3242042
Recipient Visit 3330030
Recipient Visit 3430030
Recipient Visit 3528028
Recipient Visit 3623023
Recipient Visit 3721021
Recipient Visit 3812012
Recipient Visit 3926026
Recipient Visit 4021021
Recipient Visit 4113013
Recipient Visit 4214014
Recipient Visit 4318018
Donor 112,3721,30213,674
Donor 210,3301,03611,366
Donor 36,7475997,346
Donor 45,1884235,611
Donor 53,7452974,042
Donor 62,6962172,913
Donor 71,8121471,959
Donor 81,1781071,285
Donor 980068868
Donor 1048535520
Donor 1135733390
Donor 1222920249
Donor 1312211133
Donor 1469473
Donor 1514317
Donor 17101

 

Visits (Subjects):

12/06/2018

 Serum
Total number of subjectsAverage volume (ml) per subject
Recipient Visit 11,5063.88
Recipient Visit 21,5054.54
Recipient Visit 31,5114.20
Recipient Visit 41,5084.28
Recipient Visit 51,5044.43
Recipient Visit 61,5154.35
Recipient Visit 71,5064.49
Recipient Visit 81,5094.51
Recipient Visit 91,4974.31
Recipient Visit 101,4784.49
Recipient Visit 111,4304.36
Recipient Visit 121,3134.17
Recipient Visit 131,0044.30
Recipient Visit 143894.02
Recipient Visit 152063.72
Recipient Visit 161443.71
Recipient Visit 171153.57
Recipient Visit 18983.48
Recipient Visit 19843.75
Recipient Visit 20703.81
Recipient Visit 21613.60
Recipient Visit 22423.50
Recipient Visit 23383.40
Recipient Visit 24353.44
Recipient Visit 25273.22
Recipient Visit 26222.50
Recipient Visit 27203.06
Recipient Visit 28153.08
Recipient Visit 29142.68
Recipient Visit 30132.68
Recipient Visit 31122.71
Recipient Visit 3282.63
Recipient Visit 3362.71
Recipient Visit 3452.84
Recipient Visit 3542.86
Recipient Visit 3633.37
Recipient Visit 3733.18
Recipient Visit 3832.50
Recipient Visit 3932.12
Recipient Visit 4032.50
Recipient Visit 4123.88
Recipient Visit 4231.92
Recipient Visit 4323.38
Donor 11,5134.55
Donor 21,2484.62
Donor 38184.38
Donor 46094.47
Donor 54474.45
Donor 63274.28
Donor 72274.29
Donor 81524.18
Donor 91044.11
Donor 10684.06
Donor 11494.26
Donor 12304.23
Donor 13164.00
Donor 14103.51
Donor 1534.17
Donor 1712.50
 Plasma or Serum
Total number of subjectsAverage volume (ml) per subject
Recipient Visit 19850.22
Recipient Visit 2210.25
Recipient Visit 3320.26
Recipient Visit 4850.24
Recipient Visit 52930.25
Recipient Visit 67730.26
Recipient Visit 72030.25
Recipient Visit 82890.25
Recipient Visit 96960.26
Recipient Visit 102470.24
Recipient Visit 113050.24
Recipient Visit 125910.24
Recipient Visit 131650.23
Recipient Visit 14490.24
Recipient Visit 15270.22
Recipient Visit 16190.21
Recipient Visit 17130.21
Recipient Visit 18140.19
Recipient Visit 1980.18
Recipient Visit 2070.19
Recipient Visit 2130.20
Recipient Visit 2250.17
Recipient Visit 2420.15
Recipient Visit 2510.05
Donor 19390.23
Donor 27700.23
Donor 34740.23
Donor 43340.23
Donor 52530.22
Donor 61800.23
Donor 71260.23
Donor 8900.21
Donor 9580.21
Donor 10320.20
Donor 11310.21
Donor 12180.22
Donor 13110.20
Donor 1440.24
Donor 1530.23


 

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Resources Available

Specimens Only

Materials Available

Study Documents

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