PREMIER: Lifestyle Interventions for Blood Pressure Control (PREMIER)
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Accession Number
HLB00540609a
Study Type
Clinical Trial
Collection Type
Open BioLINCC Study
See bottom of this webpage for request information
Study Period
1998-2004
NHLBI Division
DCVS
Dataset(s) Last Updated
January 3, 2018
Clinical Trial URLs
https://clinicaltrials.gov/show/NCT00000616
Primary Publication URLs
https://www.ncbi.nlm.nih.gov/pubmed/12709466
Consent
Commercial Use Data Restrictions No
Data Restrictions Based On Area Of Research No
Commercial Use Specimen Restrictions No
Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes
Genetic Use Of Specimens Allowed? Yes
Genetic Use Area Of Research Restrictions Yes
Specific Consent Restrictions
Restrictions are related to genetic/non-genetic biospecimen use by research topic.
Objectives
To determine the effect on blood pressure (BP) of 2 multicomponent, behavioral interventions.
Background
Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce BP. The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations.
Participants
Randomized trial with enrollment at 4 clinical centers (January 2000-June 2001) among 810 adults (mean [SD] age, 50 [8.9] years; 62% women; 34% African American) with above-optimal BP, including stage 1 hypertension (120-159 mm Hg systolic and 80-95 mm Hg diastolic), and who were not taking antihypertensive medications.
Design
Randomized controlled clinical trial that tested two behavioral interventions compared with an advice-only group over a period of 18 months. The two interventions promoted established recommendations that reduce BP. One intervention in addition promoted the DASH diet, which is rich in fruits, vegetables, and low-fat dairy products, and low in saturated fat, total fat, and cholesterol.
Conclusions
Individuals with above-optimal BP, including stage 1 hypertension, can make and largely sustain multiple lifestyle changes. These lifestyle changes lower BP, improve BP control, and may reduce cardiovascular disease risk. (JAMA 2003;289:2083-2093; Ann Intern Med 2006;144:485-495).
Additional Details
Premier A: 273
Premier B: 268
Premier C: 269
| Premier A | Premier B | Premier C | Total Subjects |
---|---|---|---|---|
=< 30 | 2 | 6 | 3 | 11 |
31-35 | 12 | 8 | 11 | 31 |
36-40 | 22 | 21 | 26 | 69 |
41-45 | 53 | 37 | 44 | 134 |
46-50 | 74 | 69 | 49 | 192 |
51-55 | 50 | 57 | 63 | 170 |
56-60 | 25 | 40 | 41 | 106 |
61-65 | 19 | 20 | 20 | 59 |
66-70 | 12 | 7 | 5 | 24 |
>= 71 | 4 | 3 | 7 | 14 |
| Premier A | Premier B | Premier C | Total Subjects |
---|---|---|---|---|
Male | 101 | 94 | 115 | 310 |
Female | 172 | 174 | 154 | 500 |
| Premier A | Premier B | Premier C | Total Subjects |
---|---|---|---|---|
non-Black | 173 | 168 | 190 | 531 |
Black | 100 | 100 | 79 | 279 |
Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process
Serum, Plasma, Buffy Coat, Urine
As of 02/07/2024, about 2/3 of serum specimens , 1/2 of plasma specimens, and 3/4 of urine specimens have undergone at least 1 freeze-thaw cycle. Buffy coat specimens are unthawed.
02/07/2024
| Serum | Plasma | Buffy Coat | Urine | Total Vials |
---|---|---|---|---|---|
Baseline | 3,845 | 2,553 | 791 | 6,630 | 13,819 |
6 Month | 3,581 | 2,423 | . | 5,954 | 11,958 |
18 Month | 4,175 | 2,779 | . | 7,037 | 13,991 |
Unknown | 3 | . | . | . | 3 |
02/07/2024
| Serum | |
---|---|---|
Total number of subjects | Average volume (mL) per subject | |
Baseline | 806 | 4.39 |
6 Month | 741 | 4.37 |
18 Month | 751 | 4.24 |
Unknown | 3 | 1.18 |
| Plasma | |
---|---|---|
Total number of subjects | Average volume (mL) per subject | |
Baseline | 804 | 2.84 |
6 Month | 741 | 2.92 |
18 Month | 750 | 2.90 |
| Buffy Coat | |
---|---|---|
Total number of subjects | Average volume (mL) per subject | |
Baseline | 791 | 1.01 |
| Urine | |
---|---|---|
Total number of subjects | Average volume (mL) per subject | |
Baseline | 802 | 15.12 |
6 Month | 640 | 14.85 |
18 Month | 688 | 18.98 |
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Resources Available
Specimens and Study DatasetsMaterials Available
- Buffy Coat
- Plasma
- Serum
- Urine
- More Details
Study Documents
- Data Dictionary (PDF - 512.8 KB)
- Data Collection Forms (PDF - 1.6 MB)
- Food Groups (PDF - 23.5 KB)
- MOP Clinical (PDF - 875.1 KB)
- MOP Intervention (PDF - 565.4 KB)
- PROTOCOL VER 1 8 (PDF - 561.3 KB)
- Publications (PDF - 22.5 KB)
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