PREMIER: Lifestyle Interventions for Blood Pressure Control (PREMIER)

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Accession Number
HLB00540609a

Study Type
Clinical Trial

Collection Type
Open BioLINCC Study See bottom of this webpage for request information

Study Period
1998-2004

NHLBI Division
DCVS

Dataset(s) Last Updated
January 3, 2018

Consent

Commercial Use Data Restrictions No

Data Restrictions Based On Area Of Research No

Commercial Use Specimen Restrictions No

Non-Genetic Use Specimen Restrictions Based On Area Of Use Yes

Genetic Use Of Specimens Allowed? Yes

Genetic Use Area Of Research Restrictions Yes

Specific Consent Restrictions
Restrictions are related to genetic/non-genetic biospecimen use by research topic.

Objectives

To determine the effect on blood pressure (BP) of 2 multicomponent, behavioral interventions.

Background

Weight loss, sodium reduction, increased physical activity, and limited alcohol intake are established recommendations that reduce BP. The Dietary Approaches to Stop Hypertension (DASH) diet also lowers BP. To date, no trial has evaluated the effects of simultaneously implementing these lifestyle recommendations.

Participants

Randomized trial with enrollment at 4 clinical centers (January 2000-June 2001) among 810 adults (mean [SD] age, 50 [8.9] years; 62% women; 34% African American) with above-optimal BP, including stage 1 hypertension (120-159 mm Hg systolic and 80-95 mm Hg diastolic), and who were not taking antihypertensive medications.

Design

Randomized controlled clinical trial that tested two behavioral interventions compared with an advice-only group over a period of 18 months. The two interventions promoted established recommendations that reduce BP. One intervention in addition promoted the DASH diet, which is rich in fruits, vegetables, and low-fat dairy products, and low in saturated fat, total fat, and cholesterol.

Conclusions

Individuals with above-optimal BP, including stage 1 hypertension, can make and largely sustain multiple lifestyle changes. These lifestyle changes lower BP, improve BP control, and may reduce cardiovascular disease risk. (JAMA 2003;289:2083-2093; Ann Intern Med 2006;144:485-495).

Additional Details

Subjects:

Premier A: 273

Premier B: 268

Premier C: 269

Age:

 

Premier A

Premier B

Premier C

Total Subjects

=< 30

2

6

3

11

31-35

12

8

11

31

36-40

22

21

26

69

41-45

53

37

44

134

46-50

74

69

49

192

51-55

50

57

63

170

56-60

25

40

41

106

61-65

19

20

20

59

66-70

12

7

5

24

>= 71

4

3

7

14

Sex:

 

Premier A

Premier B

Premier C

Total Subjects

Male

101

94

115

310

Female

172

174

154

500

Race:

 

Premier A

Premier B

Premier C

Total Subjects

non-Black

173

168

190

531

Black

100

100

79

279

Please note that biospecimen availability is subject to review by the NHLBI, BioLINCC, and the NHLBI Biorepository. Certain biospecimens may not be made available for your request. Section 3 of the BioLINCC handbook describes the components of the review process

Material Types:

Serum, Plasma, Buffy Coat, Urine

General Freeze/Thaw Status:

As of 02/07/2024, about 2/3 of serum specimens , 1/2 of plasma specimens, and 3/4 of urine specimens have undergone at least 1 freeze-thaw cycle. Buffy coat specimens are unthawed.

Visits (Vials):

02/07/2024

 

Serum

Plasma

Buffy Coat

Urine

Total Vials

Baseline

3,845

2,553

791

6,630

13,819

6 Month

3,581

2,423

.

5,954

11,958

18 Month

4,175

2,779

.

7,037

13,991

Unknown

3

.

.

.

3


 

Visits (Subjects):

02/07/2024

 

Serum

Total number of subjects

Average volume (mL) per subject

Baseline

806

4.39

6 Month

741

4.37

18 Month

751

4.24

Unknown

3

1.18

 

 

Plasma

Total number of subjects

Average volume (mL) per subject

Baseline

804

2.84

6 Month

741

2.92

18 Month

750

2.90

 

 

Buffy Coat

Total number of subjects

Average volume (mL) per subject

Baseline

791

1.01

 

 

Urine

Total number of subjects

Average volume (mL) per subject

Baseline

802

15.12

6 Month

640

14.85

18 Month

688

18.98

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Resources Available

Specimens and Study Datasets

Materials Available

Study Documents

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