Cerebrovascular reactivity in Alzheimer's disease signature regions is associated with mild cognitive impairment in adults with hypertension.

Pubmed ID: 38108158

Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association

Publication Date: Dec. 18, 2023

Affiliation: Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, University of California, San Diego, La Jolla, California, USA.

Grants: UL1 TR000445, UL1TR000075, 9U54TR000017-06, HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C, HHSN268200900049C, UL1RR024134, UL1RR025752, UL1RR025755, UL1RR025771, UL1TR000003, UL1TR000005, UL1TR000050, UL1TR000073, UL1TR000093, UL1TR000105-05, UL1TR000433, UL1TR000439, UL1TR001064, UL1 TR000002, UL1 TR000064

Authors: Pajewski NM, Williamson JD, Nasrallah IM, Aslanyan V, Mack WJ, Ortega NE, Pa J

Cite As: Aslanyan V, Mack WJ, Ortega NE, Nasrallah IM, Pajewski NM, Williamson JD, Pa J. Cerebrovascular reactivity in Alzheimer's disease signature regions is associated with mild cognitive impairment in adults with hypertension. Alzheimers Dement 2023 Dec 18. Epub 2023 Dec 18.

Studies:

Abstract

INTRODUCTION: Vascular risk factors contribute to cognitive decline suggesting that maintaining cerebrovascular health could reduce dementia risk. The objective of this study is to evaluate the association of cerebrovascular reactivity (CVR), a measure of brain blood vessel elasticity, with mild cognitive impairment (MCI) and dementia. METHODS: Participants were enrolled in the Systolic Blood Pressure Intervention Trial Memory and Cognition in Decreased Hypertension (SPRINT-MIND) magnetic resonance imaging substudy. Baseline CVR in Alzheimer's disease (AD) signature regions were primary variables of interest. The occipital pole and postcentral gyrus were included as control regions. RESULTS: Higher AD composite CVR was associated with lower MCI risk. No significant associations between inferior temporal gyrus, occipital pole, or postcentral gyrus CVR and MCI risk, or any regional CVR-combined risk associations were observed. DISCUSSION: CVR in AD signature regions is negatively associated with occurrence of MCI, implicating CVR in AD signature regions as a potential mechanism leading to cognitive impairment.