Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death.

Pubmed ID: 26022911

Pubmed Central ID: PMC4612521

Journal: Circulation

Publication Date: July 28, 2015

Affiliation: From Department of Epidemiology and the Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (E.S., A.M.R., J.C.); Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD (E.S., N.M., J.C.); Division of Epidemiology & Community Health (P.L.L., J.S.P.) and Department of Laboratory Medicine and Pathology (M.S.), University of Minnesota, Minneapolis.

MeSH Terms: Humans, Male, Female, Risk Factors, Middle Aged, Coronary Disease, Diabetes Complications, Heart Failure, Stroke, Survival Rate, Retrospective Studies, Serum Albumin, Biomarkers, Fructosamine, Glycation End Products, Advanced, Glycated Hemoglobin, Glycated Serum Albumin

Grants: HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, UL1 TR001079, R01 DK089174, T32 HL007024, U01 HL096812, HHSN268201100009I, HHSN268201100005G, HHSN268201100008I, HHSN268201100011I, HHSN268201100005I, HHSN268201100007I

Authors: Pankow JS, Coresh J, Lutsey PL, Selvin E, Rawlings AM, Maruthur N, Steffes M

Cite As: Selvin E, Rawlings AM, Lutsey PL, Maruthur N, Pankow JS, Steffes M, Coresh J. Fructosamine and Glycated Albumin and the Risk of Cardiovascular Outcomes and Death. Circulation 2015 Jul 28;132(4):269-77. Epub 2015 May 28.

Studies:

Abstract

BACKGROUND: Hemoglobin A1c (HbA1c) is the standard measure to monitor glucose control in diabetes mellitus and is a marker of future cardiovascular risk. Fructosamine and glycated albumin are markers of short-term glycemic control, but their associations with cardiovascular outcomes are uncharacterized. METHODS AND RESULTS: We measured glycated albumin and fructosamine in 11 104 participants with and without diabetes in the community-based Atherosclerosis Risk in Communities (ARIC) Study in 1990 to 1992 (baseline). We evaluated associations of fructosamine and glycated albumin with risk of coronary heart disease, ischemic stroke, heart failure, and mortality. We compared associations with those observed for HbA1c. During two decades of follow-up there were 1096 new cases of coronary heart disease, 605 of ischemic stroke, 1432 of heart failure, and 2860 deaths. Elevated baseline concentrations of fructosamine and glycated albumin were significantly associated with each of the outcomes even after adjustment for traditional cardiovascular risk factors, with especially strong associations in persons with diabetes mellitus. Associations were of similar magnitude to those observed for HbA1c and-as has been previously observed for HbA1c-the associations tended to be J-shaped, with an elevation of risk at the lowest levels of each biomarker. CONCLUSIONS: The acceptance of new measures of hyperglycemia is partly dependent on establishing their association with long-term outcomes. We found that fructosamine and glycated albumin were associated with vascular outcomes and mortality and that these associations were similar to those observed for HbA1c.