Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support.

Pubmed ID: 37086251

Pubmed Central ID: PMC10293076

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Publication Date: July 1, 2023

MeSH Terms: Humans, Heart Failure, Ventricular Function, Left, Heart Ventricles, Thrombosis, Heart, Heart-Assist Devices

Grants: I01 CX002291, R01 HL132067, R01 HL135121, T32 HL007576

Authors: Horne BD, Hanff TC, Kyriakopoulos CP, Sideris K, Taleb I, Griffin RJ, Sheffield E, Alharethi R, Stehlik J, Selzman CH, Drakos SG

Cite As: Kyriakopoulos CP, Horne BD, Sideris K, Taleb I, Griffin RJ, Sheffield E, Alharethi R, Hanff TC, Stehlik J, Selzman CH, Drakos SG. Left ventricular functional improvement appears to contribute to lower rates of device thrombosis in patients on durable mechanical circulatory support. J Heart Lung Transplant 2023 Jul;42(7):853-858. Epub 2023 Mar 13.

Studies:

Abstract

By unloading the failing heart, left ventricular (LV) assist devices (LVADs) provide a favorable environment for reversing adverse structural and functional cardiac changes. Prior reports have suggested that an improved native LV function might contribute to the development of LVAD thrombosis. We used the Interagency Registry for Mechanically Assisted Circulatory Support and found that LV functional improvement is associated with a lower risk for device thrombosis. The risk for cerebrovascular accident and transient ischemic attack was comparable across post-LVAD LV function subgroups, while the risk of hemolysis was lower in subgroups of patients with better LV function on LVAD support.