Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.

Pubmed ID: 25352340

Pubmed Central ID: PMC4215164

Journal: Nature communications

Publication Date: Oct. 29, 2014

MeSH Terms: Humans, Adult, Risk Factors, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Lipids, Reproducibility of Results, Homeostasis, Phenotype, Gene Expression Regulation, Iron, Genetic Association Studies, Genetic Loci, Transferrin, Ferritins, Chromosomes, Human, Pair 7, Hemochromatosis

Grants: MC_U106179471, MC_UU_12015/1, R01 AA014041, U54 EB020403, RP-PG-0310-1002, RG/09/012/28096

Authors: Uda M, Sanna S, van der Schouw YT, Wang F, Overvad K, Tjonneland A, Panico S, Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Podmore C, Luan J, Kutalik Z, van der Meer P, Tanaka T, Westra HJ, Franke L, Mihailov E, Milani L, Winkelmann J, Meitinger T, Thiery J, Peters A, Waldenberger M, Rendon A, Jolley J, Sambrook J, Kiemeney LA, Sweep FC, Sala CF, Schwienbacher C, Pichler I, Hui J, Demirkan A, Isaacs A, Amin N, Steri M, Waeber G, Verweij N, Powell JE, Nyholt DR, Heath AC, Madden PA, Visscher PM, Wright MJ, Montgomery GW, Martin NG, Hernandez D, Bandinelli S, van der Harst P, Vollenweider P, Scott RA, Scott RA, Langenberg C, Langenberg C, Wareham NJ, Wareham NJ, van Duijn C, Beilby J, Pramstaller PP, Hicks AA, Ouwehand WH, Oexle K, Gieger C, Metspalu A, Camaschella C, Toniolo D, Swinkels DW, Whitfield JB, Sharp SJ, Forouhi NG, Kerrison ND, Sims M, Barroso I, Deloukas P, McCarthy MI, Arriola L, Balkau B, Barricarte A, Schulze MB, Meidtner K, Boeing H, Franks PW, Gonzalez C, Grioni S, Kaaks R, Key TJ, Navarro C, Nilsson PM, Palli D, Quirós J, Rolandsson O, Sacerdote C, Sánchez MJ, Slimani N, Tumino R, van der A DL, Riboli E, Hälldin J

Cite As: Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D, Broer L, Podmore C, Luan J, Kutalik Z, Sanna S, van der Meer P, Tanaka T, Wang F, Westra HJ, Franke L, Mihailov E, Milani L, Hälldin J, Winkelmann J, Meitinger T, Thiery J, Peters A, Waldenberger M, Rendon A, Jolley J, Sambrook J, Kiemeney LA, Sweep FC, Sala CF, Schwienbacher C, Pichler I, Hui J, Demirkan A, Isaacs A, Amin N, Steri M, Waeber G, Verweij N, Powell JE, Nyholt DR, Heath AC, Madden PA, Visscher PM, Wright MJ, Montgomery GW, Martin NG, Hernandez D, Bandinelli S, van der Harst P, Uda M, Vollenweider P, Scott RA, Langenberg C, Wareham NJ, InterAct Consortium, van Duijn C, Beilby J, Pramstaller PP, Hicks AA, Ouwehand WH, Oexle K, Gieger C, Metspalu A, Camaschella C, Toniolo D, Swinkels DW, Whitfield JB. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun 2014 Oct 29;5:4926.

Studies:

Abstract

Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-significant (P<5 × 10(-8)) loci, some including known iron-related genes (HFE, SLC40A1, TF, TFR2, TFRC, TMPRSS6) and others novel (ABO, ARNTL, FADS2, NAT2, TEX14). SNPs at ARNTL, TF, and TFR2 affect iron markers in HFE C282Y homozygotes at risk for hemochromatosis. There is substantial overlap between our iron loci and loci affecting erythrocyte and lipid phenotypes. These results will facilitate investigation of the roles of iron in disease.