A mediation analysis assessing if interleukin-6 mediates the association between obesity and new-onset type-2-diabetes.

Pubmed ID: 40582070

Journal: Journal of diabetes and its complications

Publication Date: Sept. 1, 2025

MeSH Terms: Humans, Male, Adult, Female, Aged, Risk Factors, Middle Aged, Body Mass Index, Obesity, Diabetes Mellitus, Type 2, Inflammation, Interleukin-6, Mediation Analysis

Authors: Carris NW, Mhaskar R, Coughlin E, Bracey E, Halade GV, Yadav H, Valente MJ

Cite As: Carris NW, Mhaskar R, Coughlin E, Bracey E, Yadav H, Halade GV, Valente MJ. A mediation analysis assessing if interleukin-6 mediates the association between obesity and new-onset type-2-diabetes. J Diabetes Complications 2025 Sep;39(9):109110. Epub 2025 Jun 23.

Studies:

Abstract

Obesity and chronic low-level inflammation increase chronic disease development. The study objective was to better understand how obesity is linked to inflammation and inflammation to new-onset type-2-diabetes. This observational mediation analysis found that 8.1 % of the total effect of increasing BMI on new-onset type-2-diabetes risk was mediated by interleukin-6.