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A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study.
Pubmed ID: 24247924
Journal: European heart journal. Cardiovascular Imaging
Publication Date: March 1, 2014
MeSH Terms: Humans, Male, Adult, Female, Aged, Aged, 80 and over, Cohort Studies, Adolescent, Age Factors, Middle Aged, Sex Factors, Young Adult, Ventricular Function, Left, Echocardiography, Heart Ventricles, Reference Standards, Heart Atria, Atrial Function, Left, International Cooperation, Ethnicity
Grants: PG/05/036, MC_PC_11004
Authors: Gardin JM, de Simone G, Doughty RN, Hobbs FD, Hobbs FD, McMurray JJ, McMurray JJ, Nagueh SF, Poppe KK, Poppe KK, Poppe KK, Poppe KK, Senior R, Senior R, Thomas L, Thomas L, Whalley GA, Whalley GA, Whalley GA, Aune E, Brown A, Badano LP, Cameron V, Chadha DS, Chahal N, Chien KL, Daimon M, Dalen H, Detrano R, Akif Duzenli M, Ezekowitz J, Di Pasquale P, Fukuda S, Gill PS, Grossman E, Kim HK, Kuznetsova T, Leung NK, Linhart A, McDonagh TA, McGrady M, Mill JG, Mogelvang R, Muiesan ML, Ng AC, Ojji D, Otterstad JE, Petrovic DJ, Prendergast B, Rietzschel E, Schirmer H, Schvartzman P, Simova I, Sliwa K, Stewart S, Squire IB, Takeuchi M, Altman D, Perera R, Triggs CM, Au Yeung H, Beans Picón GA
Cite As: Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) Collaboration. A meta-analysis of echocardiographic measurements of the left heart for the development of normative reference ranges in a large international cohort: the EchoNoRMAL study. Eur Heart J Cardiovasc Imaging 2014 Mar;15(3):341-8. Epub 2013 Nov 17.
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Abstract
AIM: To develop age-, sex-, and ethnic-appropriate normative reference ranges for standard echocardiographic measurements of the left heart by combining echocardiographic measurements obtained from adult volunteers without clinical cardiovascular disease or significant cardiovascular risk factors, from multiple studies around the world. METHODS AND RESULTS: The Echocardiographic Normal Ranges Meta-Analysis of the Left heart (EchoNoRMAL) collaboration was established and population-based data sets of echocardiographic measurements combined to perform an individual person data meta-analysis. Data from 43 studies were received, representing 51 222 subjects, of which 22 404 adults aged 18-80 years were without clinical cardiovascular or renal disease, hypertension or diabetes. Quantile regression or an appropriate parametric regression method will be used to derive reference values at the 5th and 95th centile of each measurement against age. CONCLUSION: This unique data set represents a large, multi-ethnic cohort of subjects resident in a wide range of countries. The resultant reference ranges will have wide applicability for normative data based on age, sex, and ethnicity.