Outcomes and risk prediction model for peripheral arterial disease in patients with stable coronary artery disease.

Pubmed ID: 21788210

Journal: Angiology

Publication Date: Aug. 1, 2011

Affiliation: Department of Internal Medicine, Wayne State University, Detroit, MI 48201, USA.

MeSH Terms: Humans, Aged, Middle Aged, Risk Assessment, Models, Statistical, Prognosis, Peripheral Arterial Disease, Coronary Artery Disease

Authors: Veeranna V, Afonso L, Jacob S, Badheka AO, Kizilbash MA, Rathod AD, Bharadwaj AS, Bhat S, Pidlaon V

Cite As: Badheka AO, Rathod AD, Bharadwaj AS, Bhat S, Kizilbash MA, Veeranna V, Pidlaon V, Jacob S, Afonso L. Outcomes and risk prediction model for peripheral arterial disease in patients with stable coronary artery disease. Angiology 2011 Aug;62(6):473-9.

Studies:

Abstract

We used the National Heart, Lung, and Blood Institute Limited Access Dataset of Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) Trial (n = 8290) which included patients with stable coronary artery disease (CAD) and preserved ejection fraction (>40%). We identified risk factors for the development of critical peripheral arterial disease (PAD; those needing angioplasty, bypass grafting, or aneurysm repair) and formulated a risk score by multivariate analyses. A total of 220 patients (2.8%) developed critical PAD over a mean follow-up of 4.7 years. Significant predictors of critical PAD were history of intermittent claudication, smoking, hypertension (HTN), coronary-artery bypass grafting (CABG), diabetes, age, serum cholesterol, and body mass index (BMI). Incident critical PAD was associated with increased composite outcome of cardiovascular death, myocardial infarction, percutaneous transluminal coronary angioplasty, or CABG (hazard ratio 1.82, 95% CI 1.50-2.22, P < .001). Risk assessment using our score may identify CAD patients at risk for critical PAD events.