Pubmed ID: 26551272

Pubmed Central ID: PMC4689591

Journal: The New England journal of medicine

Publication Date: Nov. 26, 2015

MeSH Terms: Humans, Male, Female, Aged, Cardiovascular Diseases, Risk Factors, Age Factors, Middle Aged, Hypertension, Blood Pressure, Cause of Death, Practice Guidelines as Topic, Antihypertensive Agents, Goals

Grants: UL1 TR000445, UL1TR000075, P30 AG021332, UL1 TR000005, 9U54TR000017-06, A-HL-13-002-001, HHSN268200900040C, HHSN268200900046C, HHSN268200900047C, HHSN268200900048C, HHSN268200900049C, P30 GM103337, P30GM103337, UL1 TR000433, UL1 TR000439, UL1RR024134, UL1RR025752, UL1RR025755, UL1RR025771, UL1TR000002, UL1TR000003, UL1TR000005, UL1TR000050, UL1TR000064, UL1TR000073, UL1TR000093, UL1TR000105-05, UL1TR000433, UL1TR000439, UL1TR000445, UL1TR001064, UL1 TR000002, UL1 TR001064, UL1 TR000064, UL1 TR000075, UL1 RR025752, UL1 RR025771, UL1 TR000093, UL1 TR000003, UL1 TR000050, UL1 TR000073, UL1 RR025755, UL1 TR000105, UL1 RR024134, UL1 TR001427, UL1 TR001085

Authors: Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT, Wright JT, Cushman W, Oparil S, Cheung AK, Rocco M, Reboussin DM, Fine L, Kimmel P, Ryan L, Launer L, Moy C, Whelton P, Johnson KC, Bild D, Bonds D, Cook N, Cutler J, Fine L, Kaufmann P, Kimmel P, Launer L, Moy C, Riley W, Ryan L, Snyder J, Tolunay E, Yang S, Wright JT, Rahman M, Lerner AJ, Rahman M, Still C, Wiggers A, Zamanian S, Bee A, Dancie R, Cushman W, Wall B, Nichols L, Burns R, Martindale-Adams J, Berlowitz D, Clark E, Walsh S, Geraci T, Huff C, Shaw L, Oparil S, Lewis CE, Bradley V, Calhoun D, Glasser S, Jenkins K, Ramsey T, Cheung AK, Beddhu S, Chelune G, Childs J, Gren L, Randall A, Rocco M, Goff D, Rodriguez C, Coker L, Hawfield A, Yeboah J, Crago L, Summerson J, Hege A, Reboussin D, Williamson J, Ambrosius W, Applegate W, Evans G, Foy C, Freedman B, Kitzman D, Legault C, Lyles M, Pajewski N, Rapp S, Rushing S, Shah N, Sink KM, Vitolins M, Wagenknecht L, Wilson V, Perdue L, Woolard N, Craven T, Garcia K, Gaussoin S, Lovato L, Newman J, Amoroso B, Davis P, Griffin J, Harris D, King M, Lane K, Roberson W, Steinberg D, Ashford D, Babcock P, Chamberlain D, Christensen V, Cloud L, Collins C, Cook D, Currie K, Felton D, Harpe S, Howard M, Lewis M, Nance P, Perdue L, Puccinelli-Ortega N, Russell L, Walker J, Craven B, Goode C, Troxler M, Davis J, Hutchens S, Killeen AA, Lukkari AM, Ringer R, Dillard B, Archibeque N, Warren S, Sather M, Pontzer J, Taylor Z, Soliman EZ, Zhang ZM, Li Y, Campbell C, Hensley S, Hu J, Keasler L, Barr M, Taylor T, Bryan R, Davatzikos C, Nasarallah I, Desiderio L, Elliott M, Borthakur A, Battapady H, Erus G, Smith A, Wang Z, Doshi J, Townsend R, Cohen D, Huan Y, Duckworth M, Ford V, Sexton K, Wright JT, Lerner A, Rahman M, Still C, Bee A, Stokes DL, Smith S, Sunshine J, Clampitt M, Smith S, Welch B, Donahue M, Dagley A, Pennell D, Cannistraci C, Merkle K, Lewis J, Sika M, Wright C, Sabati M, Campuzano E, Martin H, Roman A, Cruz J, Nagornaya N, Coker L, Hege A, Maldjian J, Kaminsky S, Fuller D, Jung Y, Oparil S, Lewis B, Wadley V, Jenkins K, Ramsey T, Evanochko W, Roberson G, Corbitt T, Fisher W, Clements C, Weiner D, Wells A, Civiletto A, Aurigemma GP, Bodkin N, Norbash A, Lavoye M, Ellison A, Killiany R, Sakai O, Cheung A, Ambrosius W, Berlowitz D, Cushman W, Lewis B, Oparil S, Wright JT, Goff D, Sink K, Williamson J, Oparil S, Lewis CB, Glasser S, Bhatt U, Horwitz E, Navaneethan S, Rocco M, Hawfield A, Rodriguez C, Diamond M, Contreras G, Yeboah J, Muhlestein JB, Dwyer J, Weiner D, Simmons D, Chonchol M, Kramer H, Bates J, Servilla K, Slinin Y, Kirchner K, Fanti P, Wright C, Auchus A, Lerner A, Malik A, Asdaghi N, Kitzman D, Freedman B, Papademetriou V, Rehman S, Chapman A, Thomas G, Schreiber M, Navaneethan SD, Hickner J, Lioudis M, Lard M, Marczewski S, Maraschky J, Colman M, Aaby A, Payne S, Ramos M, Horner C, Rahman M, Drawz P, Raghavendra PP, Ober S, Mourad R, Pallaki M, Russo P, Raghavendra P, Fantauzzo P, Tucker L, Schwing B, Sedor JR, Horwitz EJ, Schellling JR, O'Toole JF, Humbert L, Tutolo W, White S, Gay A, Clark W, Hughes R, Wright JT, Dobre M, Still CH, Bee A, Williams M, Bhatt U, Hebert L, Agarwal A, Murphy MB, Ford N, Stratton C, Baxter J, Lykins AA, Neal AM, Hirmath L, Kwame O, Soe K, Miser WF, Sagrilla C, Johnston J, Anaya A, Mintos A, Howell AA, Rogers K, Taylor S, Ebersbacher D, Long L, Bednarchik B, Wiggers A, Long L, Schnall A, Smith J, Peysha L, Peysha L, Bednarchik B, Leach L, Tribout M, Harwell C, Ellington P, Banerji MA, Ghody P, Rambaud MV, Townsend R, Cohen D, Huan Y, Duckworth M, Ford V, Leshner J, Davison A, Vander Veen S, Gadegbeku CA, Gillespie A, Paranjape A, Amoroso S, Pfeffer Z, Quinn SB, He J, Chen J, Lustigova E, Malone E, Krousel-Wood M, Deichmann R, Ronney P, Muery S, Trapani D, Diamond M, Mulloy L, Hodges M, Collins M, Weathers C, Anderson H, Stone E, Walker W, McWilliams A, Dulin M, Kuhn L, Standridge S, Lowe L, Everett K, Preston K, Norton S, Gaines S, Rizvi AA, Sides AW, Herbert D, Hix MM, Whitmire M, Arnold B, Hutchinson P, Espiritu J, Feinglos M, Kovalik E, Gedon-Lipscomb G, Evans K, Thacker C, Zimmer R, Furst M, Mason M, Powell J, Bolin P, Zhang J, Pinion M, Davis G, Bryant W, Phelps P, Garris-Sutton C, Atkinson B, Contreras G, Suarez M, Schulman I, Koggan D, Vassallo J, Peruyera G, Rocco M, Hawfield A, Bethea C, Mayer S, Gilliam L, Pedley C, Zurek G, Baird M, Smoak MM, Williams J, Rogers S, Gordon L, Kennedy E, Belle B, McCorkle-Doomy J, Adams J, Chamberlain D, Lopez R, Janavs J, Rahbari-Oskoui F, Chapman A, Dollar A, Williams O, Han Y, Haley W, Fitzpatrick P, Blackshear J, Shapiro B, Harrell A, Palaj A, Henderson K, Johnson A, Gonzalez H, Robinson J, Tamariz L, Schulman I, Denizard J, Barakat R, Krishnamoorthy D, Greenway F, Monce R, Church T, Hendrick C, Yoches A, Sones L, Baltazar M, Pemu P, Jones C, Akpalu D, Dember L, Soares D, Yee J, Umanath K, Ogletree N, Thaxton S, Campana K, Sheldon D, MacArthur K, Muhlestein J, Allred N, Clements B, Dhar R, Meredith K, Le V, Miner E, Orford J, Riessen ER, Ballantyne B, Chisum B, Johnson K, Peeler D, Chertow G, Tamura M, Chang T, Erickson K, Shen J, Stafford RS, Zaharchuk G, Del Cid M, Dentinger M, Sabino J, Sahay R, Telminova EK, Weiner DE, Sarnak M, Chan L, Civiletto A, Heath A, Kantor A, Jain P, Kirkpatrick B, Well A, Yuen B, Chonchol M, Farmer B, Farmer H, Greenwald C, Malaczewski M, Lash J, Porter A, Ricardo A, Rosman RT, Cohan J, Barrera NL, Meslar D, Meslar P, Conroy MM, Unruh M, Hess R, Jhamb M, Thomas H, Fazio P, Klixbull E, Komlos-Weimer M, Mandich L, Vita T, Toto R, Van Buren P, Inrig J, Cruz M, Lightfoot T, Wang N, Webster L, Beddhu S, Raphael K, Stults B, Zaman T, Simmons D, Lavasani T, Filipowicz R, Wei G, Miller GM, Harerra J, Christensen J, Giri A, Chen X, Anderton N, Jensen A, Lewis J, Burgner A, Dwyer JP, Schulman G, Herrud T, Leavell E, McCray T, McNeil-Simaan E, Poudel M, Reed M, Sika M, Woods D, Zirkenbach JL, Raj DS, Cohen S, Patel S, Velasquez M, Bastian RS, Wing M, Roy-Chaudhury A, Depner T, Dalyrymple L, Kaysen G, Anderson S, Beddhu S, Nord J, Simmons D, Miller GM, Harerra J, Giri A, Ix JH, Goldenstein L, Miracle CM, Forbang N, Mircic M, Thomas B, Tran T, Rastogi A, Kim M, Rashid M, Lizarraga B, Hocza A, Sarmosyan K, Norris J, Sharma T, Chioy A, Bernard E, Cabrera E, Lopez C, Nunez S, Riad J, Schweitzer S, Sirop S, Thomas S, Wada L, Kramer H, Bansal V, Taylor CE, Segal MS, Hall KL, Kazory A, Gilbert L, Owens L, Poulton D, Whidden E, Blaum C, Wiggins JJ, Gure T, Nyquist L, Robinson E, Qureshi N, Ferguson K, Haider S, James M, Jones C, Renfroe K, Seay A, Weigart C, Thornley-Brown D, Rizik D, Cotton B, Fitz-Gerald M, Grimes T, Johnson C, Kennedy S, Mason C, Rosato-Burson L, Willingham R, Calhoun D, Judd E, Breaux-Shropshire T, Cook F, Medina J, Lewis J, Brantley R, Brouilette J, Glaze J, Hall S, Hiott N, Tharpe D, Boddy S, Mack C, Johnson KC, Womack C, Griffin B, Hendrix C, Johnson K, Jones L, Towers C, Punzi H, Cassidy K, Schumacher K, Irizarry C, Colon I, Colon-Ortiz P, Colon-Hernandez P, Carrasquillo M, Vazquez N, Sosa-Padilla M, Cintron-Pinero A, Ayala M, Pacheco O, Rivera C, Sotomayor-Gonzalez I, Claudio J, Lazaro J, Arce M, Heres L, Perez A, Tavarez-Valle J, Arocho F, Torres M, Vazquez M, Aurigemma GP, Takis-Smith R, Andrieni J, Bodkin N, Chaudhary K, Hu P, Kostis J, Cosgrove N, Bankowski D, Boleyn M, Casazza L, Giresi V, Patel T, Squindo E, Wu Y, Wofford M, Flessner M, Adair C, Asher J, Loope D, Cobb R, Venegas R, Bigger T, Donovan D, Lopez-Jimenez C, Tirado A, Bigger T, Getaneh A, Tang R, Durant S, Bigger T, Maurer M, Teruya S, Helmke S, Alvarez J, Campbell R, Pisoni R, Sturdivant R, Counts C, Hunt V, Spillers L, Brautigam D, Kitchen T, Gorman T, Sayers J, Button S, Chiarot J, Fischer R, Lyon M, Resnick M, Servilla K, Vigil D, Barrett T, Sweeney ME, Johnson R, McConnell S, Salles KS, Watson F, Schenk C, Whittington L, Maher M, Williams J, Swartz S, Conlin P, Alexis G, Lamkin R, Underwood P, Gomes H, Rosendorff C, Atlas S, Kwon L, Matar M, Pisoni R, Basile J, John J, Ham D, Baig H, Saklayen M, Yap J, Neff H, Miller C, Zheng-Phelan L, Gappy S, Rau S, Raman A, Berchou V, Jones E, Olgren E, Yudd M, Sastrasinh S, Michaud J, Fiore J, Kutza M, Shorr R, Mount R, Thoms J, Dunn H, Stinson S, Hunter J, Taylor A, Bates J, Anderson C, Kirchner K, Stubbs J, Hinton A, Spencer AK, Sharma S, Wiegmann T, Mehta S, Krause M, Dishongh K, Wall B, Childress R, Cushman W, Gyamlani G, Niakan A, Thompson C, Moody J, Whittle J, Barnas G, Wolfgram D, Cortese H, Johnson J, Roumie C, Hung A, Wharton J, Niesner K, Katz L, Richardson E, Brock G, Holland J, Dixon T, Zias A, Spiller C, Baker P, Felicetta J, Rehman S, Bingham K, Watnick S, Weiss J, Johnston T, Giddings S, Klein A, Rowe C, Vargo K, Waidmann K, Papademetriou V, Elkhoury JP, Gregory B, Amodeo S, Bloom M, Goldfarb-Waysman D, Treger R, Knibloe K, Ishani A, Slinin Y, Olney C, Rust J, Fanti P, Bansal S, Dunnam M, Dyer C, Hu LL, Zarate-Abbott P, Appel L, Breitner J, Davis B, Dworkin L, Johnston K, Neaton J, Taylor A, Weir M, Yancy C

Cite As: SPRINT Research Group, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, Kimmel PL, Johnson KC, Goff DC Jr, Fine LJ, Cutler JA, Cushman WC, Cheung AK, Ambrosius WT. A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med 2015 Nov 26;373(22):2103-16. Epub 2015 Nov 9.

Studies:

• Systolic Blood Pressure Intervention Trial (SPRINT)
• Systolic Blood Pressure Intervention Trial Primary Outcome Paper (SPRINT-POP) Data