Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population.

Pubmed ID: 26975902

Pubmed Central ID: PMC4889514

Journal: Clinical biochemistry

Publication Date: June 1, 2016

Affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: eselvin@jhu.edu.

MeSH Terms: Humans, Male, Adult, Female, Risk Factors, United States, Middle Aged, Risk Assessment, Prognosis, Follow-Up Studies, Heart Diseases, Cross-Sectional Studies, Biomarkers, Troponin T

Grants: HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C, R01 DK089174, T32 HL007024, K24 DK106414, HHSN268201100009I, HHSN268201100005G, HHSN268201100008I, HHSN268201100011I, HHSN268201100005I, HHSN268201100007I

Authors: Ballantyne CM, Coresh J, Selvin E, Sharrett AR, Hoogeveen R, Matsushita K, Nambi V, Rubin J, Lazo M, Blumenthal RS

Cite As: Rubin J, Matsushita K, Lazo M, Ballantyne CM, Nambi V, Hoogeveen R, Sharrett AR, Blumenthal RS, Coresh J, Selvin E. Determinants of minimal elevation in high-sensitivity cardiac troponin T in the general population. Clin Biochem 2016 Jun;49(9):657-662. Epub 2016 Mar 11.

Studies:

Atherosclerosis Risk in Communities (ARIC)

Abstract

OBJECTIVES: To study the relationship between cardiovascular risk factors and detectable cardiac troponin-T using a highly sensitive assay (hs-cTnT) among persons without a history of cardiovascular disease. DESIGN AND METHODS: We examined the cross-sectional associations between cardiovascular risk factors and hs-cTnT in 9593 participants (mean age 65.6 (SD, 5.6), 41% female, 22% black) free of cardiovascular disease in a community-based cohort, through the Atherosclerosis Risk in Communities (ARIC) Study. We used multivariable logistic regression to characterize the association between cardiovascular risk factors and detectable (≥3.0 to 13.9ng/L) and elevated (≥14.0ng/L) hs-cTnT. RESULTS: hs-cTnT was detectable in 59% and elevated in 7% of the study population. Among persons with ideal cardiovascular health, hs-cTnT was detectable in 44%. In models adjusting for significant determinants of hs-cTnT concentration, detectable hs-cTnT was more frequent among males, blacks and persons with diabetes and hypertension and less frequent among statin users, current smokers and drinkers. Other risk factors associated with detectable hs-cTnT were older age, lower kidney function and higher body mass index. These risk factors were associated with elevated hs-cTnT in a similar pattern. CONCLUSION: In a community-based sample without cardiovascular disease hs-cTnT is detectable in most adults, even among those with ideal cardiovascular health. Although most traditional cardiovascular risk factors were significant determinants of detectable and elevated hs-cTnT, the associations were particularly robust for sex, age, race, hypertension and diabetes.