Age trajectories of physiological indices in relation to healthy life course.

Pubmed ID: 21262255

Pubmed Central ID: PMC3064744

Journal: Mechanisms of ageing and development

Publication Date: March 1, 2011

Affiliation: Centre for Population Health and Aging, Duke University, Department of Sociology, Durham, NC 27708-0408, USA. konstantin.arbeev@duke.edu

MeSH Terms: Humans, Male, Adult, Female, Models, Biological, Cohort Studies, Aging, Middle Aged, Life Style, Sex Factors, Blood Pressure, Hematocrit, Stress, Physiological

Grants: R01 AG028259, R01 AG028259-05, R01AG028259, R01 AG027019, R01 AG027019-04, R01 AG030198, R01 AG030198-02, R01AG027019, R01AG030198

Authors: Yashin AI, Arbeev KG, Ukraintseva SV, Akushevich I, Kulminski AM, Arbeeva LS, Akushevich L, Culminskaya IV

Cite As: Arbeev KG, Ukraintseva SV, Akushevich I, Kulminski AM, Arbeeva LS, Akushevich L, Culminskaya IV, Yashin AI. Age trajectories of physiological indices in relation to healthy life course. Mech Ageing Dev 2011 Mar;132(3):93-102. Epub 2011 Jan 22.

Studies:

Abstract

We analysed relationship between the risk of onset of "unhealthy life" (defined as the onset of cancer, cardiovascular diseases, or diabetes) and longitudinal changes in body mass index, diastolic blood pressure, hematocrit, pulse pressure, pulse rate, and serum cholesterol in the Framingham Heart Study (Original Cohort) using the stochastic process model of human mortality and aging. The analyses demonstrate how decline in resistance to stresses and adaptive capacity accompanying human aging can be evaluated from longitudinal data. We showed how these components of the aging process, as well as deviation of the trajectories of physiological indices from those minimising the risk at respective ages, can lead to an increase in the risk of onset of unhealthy life with age. The results indicate the presence of substantial gender difference in aging related decline in stress resistance and adaptive capacity, which can contribute to differences in the shape of the sex-specific patterns of incidence rates of aging related diseases.