Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women.

Pubmed ID: 33876221

Pubmed Central ID: PMC8197565

Journal: European heart journal

Publication Date: June 1, 2021

Affiliation: School of Electrical and Electronic Engineering, The University of Adelaide, Adelaide, Australia.

MeSH Terms: Humans, Male, Female, Aged, Cardiovascular Diseases, Risk Factors, Independent Living, Sleep, Polysomnography, Arousal

Grants: R24 HL114473, R01 AG008415, R01 HL070848, R01 HL071194, R01 HL070847, R01 AG026720, R01 AR035584, U01 AG042145, R01 AG027576, T32 AG000212, R35 HL135818, R01 AG005407, U01 AG042168, R01 HL070841, R01 HL070839, R01 AR035582, U01 AR066160, UL1 TR000128, R01 AG021918, R01 AR035583, R01 HL070842, U01 AG042124, U01 AG042140, R01 HL070838, U01 AG027810, R01 AG005394, R01 HL070837, U01 AG042143, U01 AG042139, R01 AG027574

Authors: Baumert M, Shahrbabaki SS, Linz D, Hartmann S, Redline S

Cite As: Shahrbabaki SS, Linz D, Hartmann S, Redline S, Baumert M. Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women. Eur Heart J 2021 Jun 1;42(21):2088-2099.

Studies:

Abstract

AIMS: To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women. METHODS AND RESULTS: We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 ± 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 ± 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 ± 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01-2.42), P = 0.038; SHHS-women: HR 1.21 (1.06-1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04-4.50), P = 0.037; SHHS-women: HR 1.60 (1.12-2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94-1.32), P = 0.261; SHHS-men: HR 1.31 (1.06-1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02-1.79), P = 0.034; SHHS-men: HR 1.24 (0.86-1.79), P = 0.271] was less clear. CONCLUSIONS: Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.