Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study.

Pubmed ID: 26378679

Journal: Journal of hypertension

Publication Date: Dec. 1, 2015

Affiliation: University of Mississippi Medical Center, Department of Medicine, Jackson, Mississippi, USA.

MeSH Terms: Humans, Male, Adult, Female, Risk Factors, Aging, Age Factors, Middle Aged, Sex Factors, Blood Pressure, Obesity, Diabetes Mellitus, White People, Black or African American

Grants: N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022

Authors: Mosley TH, Butler KR, Penman AD, Minor DS

Cite As: Butler KR Jr, Penman AD, Minor DS, Mosley TH Jr. Determinants of pulse pressure and annual rates of change in the Atherosclerosis Risk in Communities study. J Hypertens 2015 Dec;33(12):2463-70.

Studies:

Atherosclerosis Risk in Communities (ARIC)

Abstract

INTRODUCTION: The aim of this study was to examine the effect of vascular and lifestyle risk factors on the annual rate of change in pulse pressure (PP) in a biracial, middle-aged cohort. METHODS AND RESULTS: The study population, drawn from the Atherosclerosis Risk in Communities (ARIC) cohort, included 10, 071 participants, aged 45-64 years at baseline, with a complete set of SBP and DBP readings at each of four visits 3 years apart. The average annual increase in PP was 1.23 mmHg [standard error (SE 0.01], after adjusting for baseline age differences. Compared with white men, African-American women had the highest rate of annual increase in PP (0.41 (SE 0.05) mmHg/year greater) followed by white women [0.23 (SE 0.03) mmHg/year greater] and African-American men [0.19 (SE 0.06) mmHg/year greater]. CONCLUSION: There were significant differences in both average baseline PP and average annual rate of change in PP between men and women and African-Americans and whites. Diabetes and obesity had the strongest effect on the absolute value of baseline PP and the annual rate of change in PP.