Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group.

Pubmed ID: 7745674

Pubmed Central ID: PMC189038

Journal: Journal of virology

Publication Date: June 1, 1995

Affiliation: Irwin Memorial Blood Centers, San Francisco, California, USA.

MeSH Terms: Humans, HIV Infections, HIV-1, Base Sequence, Infant, Newborn, Species Specificity, Amino Acid Sequence, Molecular Sequence Data, Phylogeny, Infant, Premature, Recombination, Genetic, Sequence Alignment, Transfusion Reaction

Grants: N01-HB-47002, N01-HB-47003, N01-HB-97074

Authors: Busch MP, Mosley JW, Diaz RS, Mayer A, Sabino EC

Cite As: Diaz RS, Sabino EC, Mayer A, Mosley JW, Busch MP. Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group. J Virol 1995 Jun;69(6):3273-81.

Studies:

Abstract

We studied a case in which a 2-month-old premature infant was concurrently transfused with packed erythrocytes from two different human immunodeficiency virus type 1 (HIV-1)-seropositive donors in late 1984. The two donors also each singly infected a second infant. Inspection of sequences from portions of the HIV-1 genomes in each of the two donors showed a close relationship to the strain in their respective singly exposed recipients. Inspection of sequences from the dually exposed recipient provided evidence of an individual simultaneously infected with two distinct HIV-1 strains, as well as recombination of the two strains in vivo.