Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes.

Pubmed ID: 38656546

Pubmed Central ID: PMC11116917

Journal: Diabetes care

Publication Date: June 1, 2024

MeSH Terms: Humans, Male, Adult, Female, Aged, Cardiovascular Diseases, Risk Factors, Middle Aged, Hypertension, Sex Factors, Blood Pressure, Age of Onset, Diabetes Mellitus, Type 2, Antihypertensive Agents

Grants: U54 AG065141, 82103908, BX20230189, U54 HL169191, U54 DK120342, U54-AG065141, ZR2021QH014, U54 HL170326

Authors: Cheng S, Ji H, Ebinger JE, Kwan AC, Reue K, Sullivan JC, Shyy J

Cite As: Ji H, Ebinger JE, Kwan AC, Reue K, Sullivan JC, Shyy J, Cheng S. Early-Onset Hypertension and Sex-Specific Residual Risk for Cardiovascular Disease in Type 2 Diabetes. Diabetes Care 2024 Jun 1;47(6):1028-1031.

Studies:

Abstract

OBJECTIVE: To investigate whether the sex disparities in type 2 diabetes-associated cardiovascular disease (CVD) risks may be related to early-onset hypertension that could benefit from intensive blood pressure (BP) control. RESEARCH DESIGN AND METHODS: We analyzed intensive versus standard BP control in relation to incident CVD events in women and men with type 2 diabetes, based on their age of hypertension diagnosis. RESULTS: Among 3,792 adults with type 2 diabetes (49% women), multivariable-adjusted CVD risk was increased per decade earlier age at hypertension diagnosis (hazard ratio 1.11 [1.03-1.21], P = 0.006). Excess risk associated with early-diagnosed hypertension was attenuated in the presence of intensive versus standard antihypertensive therapy in women (P = 0.036) but not men (P = 0.76). CONCLUSIONS: Women with type 2 diabetes and early-onset hypertension may represent a higher-risk subpopulation that not only contributes to the excess in diabetes-related CVD risk for women but may benefit from intensive BP control.