Perinatal events predicting retinopathy of prematurity in extremely pre-term infants.

Pubmed ID: 32250325

Journal: Journal of neonatal-perinatal medicine

Publication Date: Jan. 1, 2020

MeSH Terms: Humans, Male, Female, Infant, Newborn, Cardiovascular Agents, Protective Factors, Pneumonia, Ventilator-Associated, Birth Weight, Cellulitis, Cerebrospinal Fluid Shunts, Continuous Positive Airway Pressure, Ductus Arteriosus, Patent, Embolism, Air, Indomethacin, Infant, Extremely Low Birth Weight, Infant, Extremely Premature, Infant, Very Low Birth Weight, Intestinal Perforation, Mediastinal Emphysema, Meningitis, Neonatal Sepsis, Pneumopericardium, Pneumoperitoneum, Pneumothorax, Retinopathy of Prematurity, Subcutaneous Emphysema, Urinary Tract Infections

Authors: AlRyalat SA, Roto A, Alessa Z, Al Oweidat K, Al-Amer A, Khader A, Ajaj A

Cite As: AlRyalat SA, Al Oweidat K, Al-Amer A, Khader A, Ajaj A, Alessa Z, Roto A. Perinatal events predicting retinopathy of prematurity in extremely pre-term infants. J Neonatal Perinatal Med 2020;13(2):261-266.

Studies:

Abstract

BACKGROUND: Extremely preterm infants are peculiar in regard to their risk of retinopathy of prematurity (ROP). In this study, we aim to study insults that may affect extremely preterm infants, including prenatal, at birth, and postnatal insults and their effect on the development of ROP. METHODS: This study used the data from Prematurity and Respiratory Outcomes Program (PROP). All included infants with a gestational age of 23 0/7 to 28 6/7 weeks using best obstetrical estimate. We included stressful events and/or modifiable variables that may affect the normal development. We used multiple regression analysis in our statistical analysis. RESULTS: We included a total of 751 infants in our study. The mean birth weight for the included sample was 915.1 (±232.94) grams. 391 (52.1%) Infants were diagnosed with ROP. We found a significant negative correlation between ROP development and birth weight (p < 0.001), with a correlation coefficient of - 0.374. We found that the need for prophylactic indomethacin (OR 1.67), the occurrence of air leaks (OR: 2.35), ventilator-associated pneumonia (OR: 2.01), isolated bowel perforations (OR: 3.7), blood culture-proven sepsis (OR: 1.5), other infections (OR: 1.44), and receiving ventricular shunt (OR: 2.9) are significantly associated with the development of ROP. CONCLUSIONS: We believe this study included the largest number of factors studied in the largest sample of extremely premature infants. We recommend a screening program for extremely preterm infants that takes into account a scoring system with higher scores for complicated condition.