Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration.

Pubmed ID: 29649236

Pubmed Central ID: PMC5896895

Journal: PloS one

Publication Date: April 12, 2018

Link: https://air.unimi.it/retrieve/handle/2434/570170/1015302/096%20Lorenz-2018-Predictive%20value%20for%20cardiovascula.pdf?link_time=2024-07-27_15:25:55.696529

MeSH Terms: Humans, Male, Female, Aged, Cardiovascular Diseases, Risk Factors, Middle Aged, Prognosis, Carotid Intima-Media Thickness, Intersectoral Collaboration

Grants: HHSN268201200036C, N01 HC015103, N01 HC035129, N01 HC045133, N01HC55222, N01HC75150, N01HC85079, N01HC85086, R01 AG015928, R01 AG020098, R01 AG023629, R01 AG027058, R01 DE013094, R01 HL080295, R37 NS029993, U01 HL080295, R56 AG023629, MR/L003120/1, R56 AG020098, RG/13/13/30194, K24 NS062737

Authors: Franco OH, Lorenz MW, Polak JF, Kavousi M, Mathiesen EB, Völzke H, Tuomainen TP, Sander D, Plichart M, Kiechl S, Rundek T, Desvarieux M, Lind L, Gao L, Ziegelbauer K, Bots ML, Thompson SG, Srinivasan SR, Sacco RL, Hofman A, Johnsen SH, Sitzer M, Steinmetz H, Dörr M, Schminke U, Poppert H, Bickel H, Kauhanen J, Ronkainen K, Empana JP, Ducimetiere P, Norata GD, Grigore L, Willeit J, Bokemark L, Liu J, Zhao D, Rosvall M, Dekker JM, Nijpels G, Chien KL, Engström G, Hedblad B, Kitagawa K, Ikram MA, Okazaki S, Price JF, Willeit P, Bergström G, de Groot E, Iglseder B, Yanez DN, Su TC, Xie W, Lin HJ, McLachlan S, Schmidt C, Friera A, Suarez C, Gabriel R, Catapano A, Berenson G, Izzo R, Amato M, Staub D, Sirtori CR, Beloqui O, Veglia F, Uthoff H, Tremoli E, Castelnuovo S, Landecho MF, Baldassarre D, Schmidtmann I, Stehouwer CDA, Rozza F, Parraga G, Blankenberg S, Wannarong T, Espinola-Klein C, de Luca N

Cite As: Lorenz MW, Gao L, Ziegelbauer K, Norata GD, Empana JP, Schmidtmann I, Lin HJ, McLachlan S, Bokemark L, Ronkainen K, Amato M, Schminke U, Srinivasan SR, Lind L, Okazaki S, Stehouwer CDA, Willeit P, Polak JF, Steinmetz H, Sander D, Poppert H, Desvarieux M, Ikram MA, Johnsen SH, Staub D, Sirtori CR, Iglseder B, Beloqui O, Engström G, Friera A, Rozza F, Xie W, Parraga G, Grigore L, Plichart M, Blankenberg S, Su TC, Schmidt C, Tuomainen TP, Veglia F, Völzke H, Nijpels G, Willeit J, Sacco RL, Franco OH, Uthoff H, Hedblad B, Suarez C, Izzo R, Zhao D, Wannarong T, Catapano A, Ducimetiere P, Espinola-Klein C, Chien KL, Price JF, Bergström G, Kauhanen J, Tremoli E, Dörr M, Berenson G, Kitagawa K, Dekker JM, Kiechl S, Sitzer M, Bickel H, Rundek T, Hofman A, Mathiesen EB, Castelnuovo S, Landecho MF, Rosvall M, Gabriel R, de Luca N, Liu J, Baldassarre D, Kavousi M, de Groot E, Bots ML, Yanez DN, Thompson SG, PROG-IMT study group. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration. PLoS One 2018 Apr 12;13(4):e0191172. doi: 10.1371/journal.pone.0191172. eCollection 2018.

Studies:

Abstract

AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals.