Intensive blood pressure lowering reduces adverse cardiovascular outcomes among patients with high-normal glucose: An analysis from the Systolic Blood Pressure Intervention Trial database.

Pubmed ID: 29532983

Pubmed Central ID: PMC8031176

Journal: Journal of clinical hypertension (Greenwich, Conn.)

Publication Date: April 1, 2018

Affiliation: Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA.

Link: https://onlinelibrary.wiley.com/doi/pdf/10.1111/jch.13247

MeSH Terms: Humans, Male, Female, Aged, Cardiovascular Diseases, Risk Factors, Middle Aged, Hypertension, Blood Glucose, Antihypertensive Agents

Authors: Smith SM, Gong Y, Pepine CJ, Cooper-DeHoff RM, Handberg EM

Cite As: Gong Y, Smith SM, Handberg EM, Pepine CJ, Cooper-DeHoff RM. Intensive blood pressure lowering reduces adverse cardiovascular outcomes among patients with high-normal glucose: An analysis from the Systolic Blood Pressure Intervention Trial database. J Clin Hypertens (Greenwich) 2018 Apr;20(4):620-624. Epub 2018 Mar 13.

Studies:

Abstract

The objective of this analysis is to determine the effect of intensive (<120 mm Hg) versus standard (<140 mm Hg) systolic blood pressure (SBP) targets on cardiovascular (CV) outcomes among SPRINT participants with low-normal or high-normal fasting glucose (FG). We categorized the 5425 SPRINT participants with FG <100 mg/dL into 2 groups: <85 mg/dL (low-normal) and 85 to <100 mg/dL (high-normal). Among participants with low-normal glucose, there was no significant difference in the primary outcome (PO) between the 2 treatment arms (adjusted hazard ratio, HR: 1.27 (95% confidence interval [CI] 0.68-2.37, P = .46). However, the intensive SBP target was associated with 27% lower risk for the PO compared with the standard SBP target in those with high-normal glucose (HR 0.73, 0.57-0.93, P = .01). Our results indicate that hypertensive patients with high-normal FG may benefit from intensive SBP lowering, whereas benefits were inconclusive among those with low-normal FG.